Literature DB >> 24051430

Mucosal genetic immunization through microsphere-based oral carriers.

Rozita Rosli1, Nadine Nograles2, Aimi Hanafi2, Mariana Nor Shamsudin3, Syahril Abdullah1.   

Abstract

Polymeric carriers in the form of cellulose acetate phthalate (CAP) and alginate (ALG) microspheres were used for encapsulation of plasmid DNA for oral mucosal immunization. Access into the intestinal mucosa by pVAX1 eukaryotic expression plasmid vectors carrying gene-coding sequences, either for the cholera enterotoxin B subunit (ctxB) immunostimulatory antigen or the green fluorescent protein (GFP), delivered from both types of microsphere carriers were examined in orally immunized BALB/c mice. Demonstration of transgene protein expression and IgA antibody responses at local mucosal sites suggest immunological response to a potential oral DNA vaccine formulated within the microsphere carriers.

Entities:  

Keywords:  IgA; alginate; cellulose acetate phthalate; encapsulation; microspheres; mucosal immunization; plasmid DNA

Mesh：

Substances：

Year:  2013        PMID： 24051430      PMCID： PMC3906408          DOI： 10.4161/hv.25325

Source DB:  PubMed          Journal:  Hum Vaccin Immunother        ISSN： 2164-5515            Impact factor:   3.452


  22 in total

1.  Oral administration of BCG encapsulated in alginate microspheres induces strong Th1 response in BALB/c mice.

Authors:  Soheila Ajdary; Faramarz Dobakhti; Mohammad Taghikhani; Farhad Riazi-Rad; Shahnaz Rafiei; Morteza Rafiee-Tehrani
Journal:  Vaccine       Date:  2007-04-11       Impact factor: 3.641

2.  Terminology: nomenclature of mucosa-associated lymphoid tissue.

Authors:  P Brandtzaeg; H Kiyono; R Pabst; M W Russell
Journal:  Mucosal Immunol       Date:  2008-01       Impact factor: 7.313

3.  Uptake studies in rat Peyer's patches, cytotoxicity and release studies of alginate coated chitosan nanoparticles for mucosal vaccination.

Authors:  Olga Borges; Anabela Cordeiro-da-Silva; Stefan G Romeijn; Maryam Amidi; Adriano de Sousa; Gerrit Borchard; Hans E Junginger
Journal:  J Control Release       Date:  2006-06-16       Impact factor: 9.776

4.  Sustained-release tablets of indomethacin-loaded microcapsules: preparation, in vitro and in vivo characterization.

Authors:  Bin Lu; Rong Wen; Hong Yang; Yingju He
Journal:  Int J Pharm       Date:  2006-10-06       Impact factor: 5.875

Review 5.  The immune geography of IgA induction and function.

Authors:  A J Macpherson; K D McCoy; F-E Johansen; P Brandtzaeg
Journal:  Mucosal Immunol       Date:  2008-01       Impact factor: 7.313

6.  Robust gut associated vaccine-specific antibody-secreting cell responses are detected at the mucosal surface of Bangladeshi subjects after immunization with an oral killed bivalent V. cholerae O1/O139 whole cell cholera vaccine: comparison with other mucosal and systemic responses.

Authors:  Sohel Shamsuzzaman; Tanvir Ahmed; Kaiissar Mannoor; Yasmin Ara Begum; Pradip Kumar Bardhan; R Bradley Sack; David A Sack; Ann-Mari Svennerholm; Jan Holmgren; Firdausi Qadri
Journal:  Vaccine       Date:  2009-01-13       Impact factor: 3.641

7.  Protective immunity induced by oral immunization with a rotavirus DNA vaccine encapsulated in microparticles.

Authors:  S C Chen; D H Jones; E F Fynan; G H Farrar; J C Clegg; H B Greenberg; J E Herrmann
Journal:  J Virol       Date:  1998-07       Impact factor: 5.103

8.  Cellular uptake and toxicity of microparticles in a perspective of polymyxin B oral administration.

Authors:  G Coppi; M Montanari; T Rossi; M Bondi; V Iannuccelli
Journal:  Int J Pharm       Date:  2009-10-27       Impact factor: 5.875

9.  Development of novel biodegradable polymeric nanoparticles-in-microsphere formulation for local plasmid DNA delivery in the gastrointestinal tract.

Authors:  Mayank D Bhavsar; Mansoor M Amiji
Journal:  AAPS PharmSciTech       Date:  2008-01-18       Impact factor: 3.246

10.  Formation and oral administration of alginate microspheres loaded with pDNA coding for lymphocystis disease virus (LCDV) to Japanese flounder.

Authors:  Ji-Yuan Tian; Xiu-Qin Sun; Xi-Guang Chen
Journal:  Fish Shellfish Immunol       Date:  2008-02-01       Impact factor: 4.581
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  2 in total

Review 1.  Cholera toxin B: one subunit with many pharmaceutical applications.

Authors:  Keegan J Baldauf; Joshua M Royal; Krystal Teasley Hamorsky; Nobuyuki Matoba
Journal:  Toxins (Basel)       Date:  2015-03-20       Impact factor: 4.546

2.  Development of Yersinia pestis F1 antigen-loaded microspheres vaccine against plague.

Authors:  Shih-shiung Huang; I-Hsun Li; Po-da Hong; Ming-kung Yeh
Journal:  Int J Nanomedicine       Date:  2014-02-07
  2 in total

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