Literature DB >> 24050278

Allosteric modulation of Class C GPCRs: a novel approach for the treatment of CNS disorders.

Darren W Engers, Craig W Lindsley.   

Abstract

Allosteric modulation has emerged as an innovative pharmacological approach to selectively activate or inhibit several Class C GPCRs. Of the Class C GPCRs, metabotropic glutamate (mGlu) receptors represent the most promising candidates for clinical success, and both positive allosteric modulators (PAMs) and negative allosteric modulators (NAMs) of mGluRs have demonstrated therapeutic potential for a range of psychiatric and neurological disorders such as pain, depression, anxiety, cognition, Fragile X syndrome, Parkinson’s disease and schizophrenia.

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Year:  2013        PMID： 24050278      PMCID： PMC3779342          DOI： 10.1016/j.ddtec.2012.10.007

Source DB:  PubMed          Journal:  Drug Discov Today Technol        ISSN： 1740-6749


  40 in total

1.  A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential.

Authors:  Cyril Goudet; Bruno Vilar; Tiphanie Courtiol; Thierry Deltheil; Thomas Bessiron; Isabelle Brabet; Nadia Oueslati; Delphine Rigault; Hugues-Olivier Bertrand; Heather McLean; Hervé Daniel; Marianne Amalric; Francine Acher; Jean-Philippe Pin
Journal:  FASEB J       Date:  2012-01-05       Impact factor: 5.191

Review 2.  Allosteric agonists of 7TM receptors: expanding the pharmacological toolbox.

Authors:  Christopher J Langmead; Arthur Christopoulos
Journal:  Trends Pharmacol Sci       Date:  2006-08-04       Impact factor: 14.819

Review 3.  Allosteric modulation of G protein-coupled receptors.

Authors:  Lauren T May; Katie Leach; Patrick M Sexton; Arthur Christopoulos
Journal:  Annu Rev Pharmacol Toxicol       Date:  2007       Impact factor: 13.820

Review 4.  Allosteric modulation of kinases and GPCRs: design principles and structural diversity.

Authors:  Jana A Lewis; Evan P Lebois; Craig W Lindsley
Journal:  Curr Opin Chem Biol       Date:  2008-04-18       Impact factor: 8.822

Review 5.  G-protein-coupled receptors: from classical modes of modulation to allosteric mechanisms.

Authors:  Thomas M Bridges; Craig W Lindsley
Journal:  ACS Chem Biol       Date:  2008-07-25       Impact factor: 5.100

Review 6.  Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics.

Authors:  Albert J Robichaud; Darren W Engers; Craig W Lindsley; Corey R Hopkins
Journal:  ACS Chem Neurosci       Date:  2011-06-14       Impact factor: 4.418

7.  Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM.

Authors:  Douglas J Sheffler; Cody J Wenthur; Joshua A Bruner; Sheridan J S Carrington; Paige N Vinson; Kiran K Gogi; Anna L Blobaum; Ryan D Morrison; Mitchell Vamos; Nicholas D P Cosford; Shaun R Stauffer; J Scott Daniels; Colleen M Niswender; P Jeffrey Conn; Craig W Lindsley
Journal:  Bioorg Med Chem Lett       Date:  2012-04-30       Impact factor: 2.823

8.  LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors.

Authors:  D D Schoepp; B G Johnson; R A Wright; C R Salhoff; N G Mayne; S Wu; S L Cockerman; J P Burnett; R Belegaje; D Bleakman; J A Monn
Journal:  Neuropharmacology       Date:  1997-01       Impact factor: 5.250

Review 9.  Metabotropic glutamate receptors: physiology, pharmacology, and disease.

Authors:  Colleen M Niswender; P Jeffrey Conn
Journal:  Annu Rev Pharmacol Toxicol       Date:  2010       Impact factor: 13.820

10.  Clustered coding variants in the glutamate receptor complexes of individuals with schizophrenia and bipolar disorder.

Authors:  René A W Frank; Allan F McRae; Andrew J Pocklington; Louie N van de Lagemaat; Pau Navarro; Mike D R Croning; Noboru H Komiyama; Sophie J Bradley; R A John Challiss; J Douglas Armstrong; Robert D Finn; Mary P Malloy; Alan W MacLean; Sarah E Harris; John M Starr; Sanjeev S Bhaskar; Eleanor K Howard; Sarah E Hunt; Alison J Coffey; Venkatesh Ranganath; Panos Deloukas; Jane Rogers; Walter J Muir; Ian J Deary; Douglas H Blackwood; Peter M Visscher; Seth G N Grant
Journal:  PLoS One       Date:  2011-04-29       Impact factor: 3.240
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  9 in total

1.  Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu1 Receptors Found in Schizophrenics.

Authors:  Pedro M Garcia-Barrantes; Hyekyung P Cho; Colleen M Niswender; Frank W Byers; Charles W Locuson; Anna L Blobaum; Zixiu Xiang; Jerri M Rook; P Jeffrey Conn; Craig W Lindsley
Journal:  J Med Chem       Date:  2015-10-08       Impact factor: 7.446

Review 2.  Effect of Novel Allosteric Modulators of Metabotropic Glutamate Receptors on Drug Self-administration and Relapse: A Review of Preclinical Studies and Their Clinical Implications.

Authors:  Daniele Caprioli; Zuzana Justinova; Marco Venniro; Yavin Shaham
Journal:  Biol Psychiatry       Date:  2017-09-05       Impact factor: 13.382

Review 3.  Structural biology of GABAB receptor.

Authors:  Aurel Frangaj; Qing R Fan
Journal:  Neuropharmacology       Date:  2017-10-12       Impact factor: 5.273

4.  Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses.

Authors:  Ayaka Tobo; Masayuki Tobo; Takashi Nakakura; Masashi Ebara; Hideaki Tomura; Chihiro Mogi; Dong-Soon Im; Naoya Murata; Atsushi Kuwabara; Saki Ito; Hayato Fukuda; Mitsuhiro Arisawa; Satoshi Shuto; Michio Nakaya; Hitoshi Kurose; Koichi Sato; Fumikazu Okajima
Journal:  PLoS One       Date:  2015-06-12       Impact factor: 3.240

5.  Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics.

Authors:  Hyekyung P Cho; Pedro M Garcia-Barrantes; John T Brogan; Corey R Hopkins; Colleen M Niswender; Alice L Rodriguez; Daryl F Venable; Ryan D Morrison; Michael Bubser; J Scott Daniels; Carrie K Jones; P Jeffrey Conn; Craig W Lindsley
Journal:  ACS Chem Biol       Date:  2014-08-28       Impact factor: 5.100

Review 6.  The GABAB Receptor-Structure, Ligand Binding and Drug Development.

Authors:  Linn Samira Mari Evenseth; Mari Gabrielsen; Ingebrigt Sylte
Journal:  Molecules       Date:  2020-07-07       Impact factor: 4.411

7.  Virtual Screening and Molecular Dynamics Study of Potential Negative Allosteric Modulators of mGluR1 from Chinese Herbs.

Authors:  Ludi Jiang; Xianbao Zhang; Xi Chen; Yusu He; Liansheng Qiao; Yanling Zhang; Gongyu Li; Yuhong Xiang
Journal:  Molecules       Date:  2015-07-15       Impact factor: 4.411

Review 8.  Neurobiological Insights from mGlu Receptor Allosteric Modulation.

Authors:  Daniel E O'Brien; P Jeffrey Conn
Journal:  Int J Neuropsychopharmacol       Date:  2016-04-29       Impact factor: 5.176

Review 9.  Family C G-Protein-Coupled Receptors in Alzheimer's Disease and Therapeutic Implications.

Authors:  Ilaria Dal Prà; Ubaldo Armato; Anna Chiarini
Journal:  Front Pharmacol       Date:  2019-10-28       Impact factor: 5.810
  9 in total

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