Carol Di Perri1, Stefano Bastianello, Andreas J Bartsch, Caterina Pistarini, Giorgio Maggioni, Lorenzo Magrassi, Roberto Imberti, Anna Pichiecchio, Paolo Vitali, Steven Laureys, Francesco Di Salle. 1. From the Department of Neuroradiology (C.D.P., A.P., P.V.), National Neurological Institute C. Mondino, Pavia; Department of Neuroradiology (S.B.), Neurological Institute C. Mondino, University of Pavia, Italy; Coma Science Group (C.D.P., S.L.), Cyclotron Research Centre and Neurology Department, University and University Hospital of Liège, Belgium; Department of Cognitive Neuroscience (C.D.P., F.D.S.), Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Department of Neuroradiology (A.J.B.), University of Heidelberg, Germany; Functional MRI of the Brain (A.J.B.), University of Oxford, UK; Neurorehabilitation Unit (C.P., G.M.), IRCCS, S. Maugeri Foundation, Via Maugeri, Pavia, Italy; Department of Surgical Sciences, University of Pavia (L.M.), Department of Anesthesiology and Critical Care Medicine (R.I.), Fondazione IRCCS, Policlinico S. Matteo, Pavia; University of Salerno (F.D.S.), Medical Faculty; and Fondazione Eugenio Medea (F.D.S.), Lecco, Italy.
Abstract
OBJECTIVE: To investigate functional connectivity between the default mode network (DMN) and other networks in disorders of consciousness. METHODS: We analyzed MRI data from 11 patients in a vegetative state and 7 patients in a minimally conscious state along with age- and sex-matched healthy control subjects. MRI data analysis included nonlinear spatial normalization to compensate for disease-related anatomical distortions. We studied brain connectivity data from resting-state MRI temporal series, combining noninferential (independent component analysis) and inferential (seed-based general linear model) methods. RESULTS: In DMN hypoconnectivity conditions, a patient's DMN functional connectivity shifts and paradoxically increases in limbic structures, including the orbitofrontal cortex, insula, hypothalamus, and the ventral tegmental area. CONCLUSIONS: Concurrently with DMN hypoconnectivity, we report limbic hyperconnectivity in patients in vegetative and minimally conscious states. This hyperconnectivity may reflect the persistent engagement of residual neural activity in self-reinforcing neural loops, which, in turn, could disrupt normal patterns of connectivity.
OBJECTIVE: To investigate functional connectivity between the default mode network (DMN) and other networks in disorders of consciousness. METHODS: We analyzed MRI data from 11 patients in a vegetative state and 7 patients in a minimally conscious state along with age- and sex-matched healthy control subjects. MRI data analysis included nonlinear spatial normalization to compensate for disease-related anatomical distortions. We studied brain connectivity data from resting-state MRI temporal series, combining noninferential (independent component analysis) and inferential (seed-based general linear model) methods. RESULTS: In DMN hypoconnectivity conditions, a patient's DMN functional connectivity shifts and paradoxically increases in limbic structures, including the orbitofrontal cortex, insula, hypothalamus, and the ventral tegmental area. CONCLUSIONS: Concurrently with DMN hypoconnectivity, we report limbic hyperconnectivity in patients in vegetative and minimally conscious states. This hyperconnectivity may reflect the persistent engagement of residual neural activity in self-reinforcing neural loops, which, in turn, could disrupt normal patterns of connectivity.
Authors: Charlène Aubinet; Stephen Karl Larroque; Lizette Heine; Charlotte Martial; Steve Majerus; Steven Laureys; Carol Di Perri Journal: Hum Brain Mapp Date: 2018-07-04 Impact factor: 5.038
Authors: D Pugin; J Hofmeister; Y Gasche; S Vulliemoz; K-O Lövblad; D Van De Ville; S Haller Journal: AJNR Am J Neuroradiol Date: 2020-05-21 Impact factor: 3.825