Literature DB >> 24047270

Chromenes: potential new chemotherapeutic agents for cancer.

Shivaputra A Patil1, Renukadevi Patil, Lawrence M Pfeffer, Duane D Miller.   

Abstract

Cancer is a major devastating disease, and is a leading cause of death worldwide. Despite the progress in cancer treatment, cancer mortality rate remains high. Therefore, the discovery and development of improved anticancer drugs to treat cancer are needed. 4H-chromenes have strong cytotoxicity against a panel of human cancer cell lines involving pathways that include microtubule depolarization and tumor vasculature disruption. A chromene analog, Crolibulin™ (EPC2407) is currently in Phase I/II clinical trials for the treatment of advanced solid tumors. This article reviews the general synthesis, biological activities and structure-activity relatinships of different classes of chromenes.

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Year:  2013        PMID： 24047270     DOI： 10.4155/fmc.13.126

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   3.808


  7 in total

Review 1.  A decennary update on applications of metal nanoparticles (MNPs) in the synthesis of nitrogen- and oxygen-containing heterocyclic scaffolds.

Authors:  Tejas M Dhameliya; Hiren A Donga; Punit V Vaghela; Bhoomi G Panchal; Dipen K Sureja; Kunjan B Bodiwala; Mahesh T Chhabria
Journal:  RSC Adv       Date:  2020-09-03       Impact factor: 4.036

2.  Synthesis and characterization of novel 2-amino-chromene-nitriles that target Bcl-2 in acute myeloid leukemia cell lines.

Authors:  Hosadurga K Keerthy; Manoj Garg; Chakrabhavi D Mohan; Vikas Madan; Deepika Kanojia; Rangappa Shobith; Shivananju Nanjundaswamy; Daniel J Mason; Andreas Bender; Kanchugarakoppal S Rangappa; H Phillip Koeffler
Journal:  PLoS One       Date:  2014-09-30       Impact factor: 3.240

3.  Assembly of fully substituted triazolochromenes via a novel multicomponent reaction or mechanochemical synthesis.

Authors:  Robby Vroemans; Yenthel Verhaegen; My Tran Thi Dieu; Wim Dehaen
Journal:  Beilstein J Org Chem       Date:  2018-10-22       Impact factor: 2.883

4.  Design of New Benzo[h]chromene Derivatives: Antitumor Activities and Structure-Activity Relationships of the 2,3-Positions and Fused Rings at the 2,3-Positions.

Authors:  Rawda M Okasha; Fawzia F Alblewi; Tarek H Afifi; Arshi Naqvi; Ahmed M Fouda; Al-Anood M Al-Dies; Ahmed M El-Agrody
Journal:  Molecules       Date:  2017-03-18       Impact factor: 4.411

5.  Introducing novel potent anticancer agents of 1H-benzo[f]chromene scaffolds, targeting c-Src kinase enzyme with MDA-MB-231 cell line anti-invasion effect.

Authors:  Hany E A Ahmed; Mohammed A A El-Nassag; Ahmed H Hassan; Rawda M Okasha; Saleh Ihmaid; Ahmed M Fouda; Tarek H Afifi; Ateyatallah Aljuhani; Ahmed M El-Agrody
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051

6.  Cysteic acid grafted to magnetic graphene oxide as a promising recoverable solid acid catalyst for the synthesis of diverse 4H-chromene.

Authors:  Firouz Matloubi Moghaddam; Mohammad Eslami; Golfamsadat Hoda
Journal:  Sci Rep       Date:  2020-12-01       Impact factor: 4.379

7.  Green and Mechanochemical One-Pot Multicomponent Synthesis of Bioactive 2-amino-4H-benzo[b]pyrans via Highly Efficient Amine-Functionalized SiO2@Fe3O4 Nanoparticles.

Authors:  Preeti Singh; Priyanka Yadav; Anupam Mishra; Satish K Awasthi
Journal:  ACS Omega       Date:  2020-02-20
  7 in total

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