Literature DB >> 24046143

miR-125b inhibits Connexin43 and promotes glioma growth.

Zheng Jin1, Songbai Xu, Hongquan Yu, Boyu Yang, Hongguang Zhao, Gang Zhao.   

Abstract

MicroRNA is strongly associated with tumor growth and development. This study examined the potential roles of miR-125b in glioma growth. We found that miR-125b promotes glioma cell line growth and clone formation, and protects the glioma cells from apoptosis in vitro. The miR-125b-transfected glioma cells also demonstrated increased growth after in vivo transplantation. We further identified that miR-125b inhibits Connexin43 expression, and the overexpression of Connexin43 antagonizes the effects of miR-125b in cell growth and anti-apoptosis. We conclude that miR-125b regulates glioma growth partly through Connexin43 protein.

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Year:  2013        PMID： 24046143     DOI： 10.1007/s10571-013-9980-1

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  26 in total

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