OBJECTIVES: To assess the frequency of systemic mastocytosis (SM) in a large series of acute myeloid leukemia (AML) with t(8;21)(q22;q22). METHODS: We retrospectively characterized 40 bone marrow aspirate smears and biopsy specimens from patients with AML with t(8;21) for the presence of SM. Cases were assessed for mast cell morphology and immunohistochemistry, as well as KIT exon 8 and 17 mutational assessment by reverse transcription polymerase chain reaction. RESULTS: Four patients met criteria for SM, 1 met criteria for myelomastocytic leukemia, and 8 demonstrated the benign finding of mast cell hyperplasia. CONCLUSIONS: We recommend examining all cases of AML with t(8;21) for the presence of SM via morphology, immunophenotyping, and KIT mutational analysis studies.
OBJECTIVES: To assess the frequency of systemic mastocytosis (SM) in a large series of acute myeloid leukemia (AML) with t(8;21)(q22;q22). METHODS: We retrospectively characterized 40 bone marrow aspirate smears and biopsy specimens from patients with AML with t(8;21) for the presence of SM. Cases were assessed for mast cell morphology and immunohistochemistry, as well as KIT exon 8 and 17 mutational assessment by reverse transcription polymerase chain reaction. RESULTS: Four patients met criteria for SM, 1 met criteria for myelomastocytic leukemia, and 8 demonstrated the benign finding of mast cell hyperplasia. CONCLUSIONS: We recommend examining all cases of AML with t(8;21) for the presence of SM via morphology, immunophenotyping, and KIT mutational analysis studies.
Entities:
Keywords:
AML with t(8;21); CD25; D816V; Exon 17 KIT mutations; Myelomastocytic leukemia; N822K; Systemic mastocytosis; Tryptase
Authors: Celalettin Ustun; Andreas Reiter; Bart L Scott; Ryotaro Nakamura; Gandhi Damaj; Sebastian Kreil; Ryan Shanley; William J Hogan; Miguel-Angel Perales; Tsiporah Shore; Herrad Baurmann; Robert Stuart; Bernd Gruhn; Michael Doubek; Jack W Hsu; Eleni Tholouli; Tanja Gromke; Lucy A Godley; Livio Pagano; Andrew Gilman; Eva Maria Wagner; Tor Shwayder; Martin Bornhäuser; Esperanza B Papadopoulos; Alexandra Böhm; Gregory Vercellotti; Maria Teresa Van Lint; Christoph Schmid; Werner Rabitsch; Vinod Pullarkat; Faezeh Legrand; Ibrahim Yakoub-Agha; Wael Saber; John Barrett; Olivier Hermine; Hans Hagglund; Wolfgang R Sperr; Uday Popat; Edwin P Alyea; Steven Devine; H Joachim Deeg; Daniel Weisdorf; Cem Akin; Peter Valent Journal: J Clin Oncol Date: 2014-08-25 Impact factor: 44.544
Authors: Jeffrey W Craig; Robert P Hasserjian; Annette S Kim; Jon C Aster; Geraldine S Pinkus; Jason L Hornick; David P Steensma; R Coleman Lindsley; Daniel J DeAngelo; Elizabeth A Morgan Journal: Mod Pathol Date: 2020-01-02 Impact factor: 7.842
Authors: Feryal Abbas Ibrahim Hilmi; Ahmad Al-Sabbagh; Dina Sameh Soliman; Hesham Al Sabah; Omar Mohammad Ismail; Mohamed Yassin; Halima El-Omri Journal: Clin Med Insights Blood Disord Date: 2017-03-30
Authors: Won Kyu Choi; Young Uk Cho; Eunkyoung You; Seongsoo Jang; Eul Ju Seo; Chan Jeoung Park Journal: Ann Lab Med Date: 2017-05 Impact factor: 3.464
Authors: Siba El Hussein; Helen T Chifotides; Joseph D Khoury; Srdan Verstovsek; Beenu Thakral Journal: Cancers (Basel) Date: 2022-07-17 Impact factor: 6.575
Authors: Peter Valent; Wolfgang R Sperr; Karl Sotlar; Andreas Reiter; Cem Akin; Jason Gotlib; Hans-Peter Horny; Michel Arock Journal: Expert Rev Hematol Date: 2014-08-28 Impact factor: 2.929
Authors: Feryal A Ibrahim; Mohammad A J Abdulla; Dina Soliman; Ahmad Al Sabbagh; Zafar Nawaz; Susanna Jane Akiki; Hawraa Shwaylia; Mohamed A Yassin Journal: Am J Case Rep Date: 2020-05-13