Literature DB >> 24045294

The mode of action of anticancer gold-based drugs: a structural perspective.

Luigi Messori1, Federica Scaletti, Lara Massai, Maria A Cinellu, Chiara Gabbiani, Alessandro Vergara, Antonello Merlino.   

Abstract

The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug-protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds and the inherent protein metalation processes.

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Year:  2013        PMID： 24045294     DOI： 10.1039/c3cc46400h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  11 in total

1.  Protein Recognition of Gold-Based Drugs: 3D Structure of the Complex Formed When Lysozyme Reacts with Aubipy(c.).

Authors:  Luigi Messori; Maria Agostina Cinellu; Antonello Merlino
Journal:  ACS Med Chem Lett       Date:  2014-07-31       Impact factor: 4.345

2.  Inhibition Mechanism of Urease by Au(III) Compounds Unveiled by X-ray Diffraction Analysis.

Authors:  Luca Mazzei; Margot N Wenzel; Michele Cianci; Marta Palombo; Angela Casini; Stefano Ciurli
Journal:  ACS Med Chem Lett       Date:  2019-01-04       Impact factor: 4.345

3.  Targeting Zinc Finger Proteins with Exogenous Metals and Molecules: Lessons learned from Tristetraprolin, a CCCH type Zinc Finger.

Authors:  Kiwon Ok; Milos R Filipovic; Sarah L J Michel
Journal:  Eur J Inorg Chem       Date:  2021-07-21       Impact factor: 2.551

4.  The influence of oxo-bridged binuclear gold(III) complexes on Na/K-ATPase activity: a joint experimental and theoretical approach.

Authors:  Aleksandra M Bondžić; Mirjana B Čolović; Goran V Janjić; Božidarka Zarić; Sandra Petrović; Danijela Z Krstić; Tiziano Marzo; Luigi Messori; Vesna M Vasić
Journal:  J Biol Inorg Chem       Date:  2017-04-21       Impact factor: 3.358

5.  Effect of temperature on the interaction of cisplatin with the model protein hen egg white lysozyme.

Authors:  Giarita Ferraro; Andrea Pica; Irene Russo Krauss; Francesca Pane; Angela Amoresano; Antonello Merlino
Journal:  J Biol Inorg Chem       Date:  2016-04-04       Impact factor: 3.358

6.  Novel antitumor adamantane-azole gold(I) complexes as potential inhibitors of thioredoxin reductase.

Authors:  Adriana Garcia; Rafael Carvalhaes Machado; Richard Michael Grazul; Miriam Teresa Paz Lopes; Charlane Cimini Corrêa; Hélio F Dos Santos; Mauro Vieira de Almeida; Heveline Silva
Journal:  J Biol Inorg Chem       Date:  2016-02-03       Impact factor: 3.358

7.  Reactivity of the [Au(C^N^C)Cl] complex in the presence of H2O and N-, S- and Se-containing nucleophiles: a DFT study.

Authors:  G Y Sánchez Delgado; D Paschoal; H F Dos Santos
Journal:  J Biol Inorg Chem       Date:  2018-09-12       Impact factor: 3.358

8.  Allosteric cross-talk in chromatin can mediate drug-drug synergy.

Authors:  Zenita Adhireksan; Giulia Palermo; Tina Riedel; Zhujun Ma; Reyhan Muhammad; Ursula Rothlisberger; Paul J Dyson; Curt A Davey
Journal:  Nat Commun       Date:  2017-03-30       Impact factor: 14.919

9.  Unusual Structural Features in the Adduct of Dirhodium Tetraacetate with Lysozyme.

Authors:  Domenico Loreto; Giarita Ferraro; Antonello Merlino
Journal:  Int J Mol Sci       Date:  2021-02-02       Impact factor: 5.923

Review 10.  Computational Studies of Au(I) and Au(III) Anticancer MetalLodrugs: A Survey.

Authors:  Iogann Tolbatov; Alessandro Marrone; Cecilia Coletti; Nazzareno Re
Journal:  Molecules       Date:  2021-12-15       Impact factor: 4.411
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