Tao Zhang1, Joshua E Lubek2, Andrew Salama3, Donita Dyalram2, Xinggang Liu4, Robert A Ord5. 1. Associate Professor, Department of Stomatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China. Electronic address: drtzhang@gmail.com. 2. Assistant Professor, Department of Oral and Maxillofacial Surgery, Greenebaum Cancer Center, University of Maryland, Baltimore, MD. 3. Assistant Professor, Department of Oral and Maxillofacial surgery, Boston University Medical Center, Boston, MA. 4. Post Graduate Doctoral Fellow, Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, MD. 5. Professor, Department of Oral and Maxillofacial Surgery, Greenebaum Cancer Center, University of Maryland, Baltimore, MD.
Abstract
PURPOSE: The objective of the present study was to summarize the treatment and outcomes of cT1N0M0 tongue cancer for which the management is less defined. MATERIALS AND METHODS: A total of 65 consecutive cases of cT1 tongue cancer were retrospectively reviewed. The Fisher exact, χ(2), and Wilcoxon tests were used to statistically analyze the data. RESULTS: The tumor depth had a significant relation to the presence of neck metastasis (P < .05). A 3-mm cutoff point provided better predictive value, with a sensitivity of 92.9% and specificity of 43.1%. The biopsy depth combined with palpation was accurate in determining the tumor depth preoperatively in 87.7%. On multivariate analysis, only the tumor site (ventral tongue) and the presence of erythroleukoplakia had any significant relation to disease-free survival (P = .010). CONCLUSIONS: Elective neck dissection should be considered for patients with cT1N0 oral tongue squamous carcinoma with a biopsy depth of 3 mm or greater. The biopsy depth, combined with the clinical examination findings, is a useful method to help determine the tumor depth preoperatively.
PURPOSE: The objective of the present study was to summarize the treatment and outcomes of cT1N0M0 tongue cancer for which the management is less defined. MATERIALS AND METHODS: A total of 65 consecutive cases of cT1tongue cancer were retrospectively reviewed. The Fisher exact, χ(2), and Wilcoxon tests were used to statistically analyze the data. RESULTS: The tumor depth had a significant relation to the presence of neck metastasis (P < .05). A 3-mm cutoff point provided better predictive value, with a sensitivity of 92.9% and specificity of 43.1%. The biopsy depth combined with palpation was accurate in determining the tumor depth preoperatively in 87.7%. On multivariate analysis, only the tumor site (ventral tongue) and the presence of erythroleukoplakia had any significant relation to disease-free survival (P = .010). CONCLUSIONS: Elective neck dissection should be considered for patients with cT1N0 oral tongue squamous carcinoma with a biopsy depth of 3 mm or greater. The biopsy depth, combined with the clinical examination findings, is a useful method to help determine the tumor depth preoperatively.
Authors: Nootan Kumar Shukla; S V Suryanarayana Deo; Pankaj Kumar Garg; N M L Manjunath; Suman Bhaskar; V Sreenivas Journal: Indian J Surg Oncol Date: 2017-05-11
Authors: Thomas Mücke; David A Mitchell; Stefan Wagenpfeil; Lucas M Ritschl; Klaus-Dietrich Wolff; Anastasios Kanatas Journal: BMC Cancer Date: 2014-05-20 Impact factor: 4.430