| Literature DB >> 24045100 |
B G Schreurs1, C A Smith-Bell, S K Lemieux.
Abstract
Using structural magnetic resonance imaging in a clinical scanner at 3.0T, we describe results showing that following 12weeks on a diet of 2% cholesterol, rabbits experience a significant increase in the volume of the third ventricle compared to rabbits on a diet of 0% cholesterol. Using time-of-flight magnetic resonance angiography, we find cholesterol-fed rabbits also experience a decrease in the diameter of a number of cerebral blood vessels including the basilar, posterior communicating, and internal carotid arteries. Taken together, these data confirm that, despite the inability of dietary cholesterol to cross the blood-brain barrier, it does significantly enlarge ventricular volume and decrease cerebrovascular diameter in the rabbit - effects that are also seen in patients with Alzheimer's disease.Entities:
Keywords: AD; Alzheimer’s disease; MIP; MPRAGE; MRI; TOF; animal model; apoE; apolipoprotein E; cerebrovasculature; copper; magnetic resonance imaging; magnetization prepared reduced angle gradient echo sequence; maximum intensity projection; time-of-flight; ventricle
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Year: 2013 PMID： 24045100 PMCID： PMC3830722 DOI： 10.1016/j.neuroscience.2013.09.015
Source DB: PubMed Journal: Neuroscience ISSN： 0306-4522 Impact factor: 3.590