| Literature DB >> 24045010 |
Elena Zambrano1, Carolina Guzmán2, Guadalupe L Rodríguez-González3, Marta Durand-Carbajal3, Peter W Nathanielsz4.
Abstract
The recent growth of interest in developmental programming of physiological systems has generally focused on the cardiovascular system (especially hypertension) and predisposition to metabolic dysfunction (mainly obesity and diabetes). However, it is now clear that the full range of altered offspring phenotypes includes impaired reproductive function. In rats, sheep and nonhuman primates, reproductive capacity is altered by challenges experienced during critical periods of development. This review will examine available experimental evidence across commonly studied experimental species for developmental programming of female and male reproductive function throughout an individual's life-course. It is necessary to consider events that occur during fetal development, early neonatal life and prior to and during puberty, during active reproductive life and aging as reproductive performance declines.Entities:
Keywords: 11β-HSD2; 11β-hydroxysteroid dehydrogenase type 2; ACTH; AMH; AR; DES; DHT; ER; FSH; Fetal; GR; Glucocorticoids; GnRH; HPA; IUGR; LH; Maternal obesity; Maternal undernutrition; Neonatal; P450 side chain cleavage; P450scc; PR; Sex steroids; StAR; adrenocorticotropic hormone; androgen receptor; antimullerian hormone; diethylstilbestrol; dihydrotestosterone; estrogen receptor; follicle-stimulating hormone; glucocorticoid receptor; gonadotropin-releasing hormone; hypothalamic–pituitary–adrenal; intrauterine growth restriction; luteinizing hormone; progesterone receptor; steroid acute regulatory protein
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Year: 2013 PMID： 24045010 DOI： 10.1016/j.mce.2013.09.008
Source DB: PubMed Journal: Mol Cell Endocrinol ISSN： 0303-7207 Impact factor: 4.102