Literature DB >> 24044038

ERK1/2 in the brain mediates the effects of central resistin on reducing thermogenesis in brown adipose tissue.

Samin Kosari1, Donny M Camera, John A Hawley, Martin Stebbing, Emilio Badoer.   

Abstract

We investigated the role of ERK1/2 in the brain on the effects of centrally administered resistin on thermogenesis. Resistin (7 μg) into anaesthetized rats significantly decreased brown adipose tissue temperature by 1.0 ± 0.4 °C (P < 0.005). This response was significantly attenuated by over 60% when ERK1/2 was inhibited by U0126 (7 μg) (P < 0.05). Resistin reduced uncoupling protein-1 mRNA expression (0.11 ± 0.01 vs 1.24 ± 0.85 resistin vs control respectively) and the expression of peroxisome proliferator-activated receptor gamma co-activator 1-α, but the effects were not statistically significant. The results suggest that ERK1/2 in the brain contributes to resistin's effects on thermogenesis.

Entities:  

Keywords:  ERK1/2; Resistin; brown adipose tissue; thermogenesis

Year:  2013        PMID： 24044038      PMCID： PMC3773078     

Source DB:  PubMed          Journal:  Int J Physiol Pathophysiol Pharmacol        ISSN： 1944-8171


  20 in total

1.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

Authors:  K J Livak; T D Schmittgen
Journal:  Methods       Date:  2001-12       Impact factor: 3.608

2.  Central administration of resistin promotes short-term satiety in rats.

Authors:  Sulay Tovar; Rubén Nogueiras; Loraine Y C Tung; Tamara R Castañeda; María Jesús Vázquez; Amanda Morris; Lynda M Williams; Suzanne L Dickson; Carlos Diéguez
Journal:  Eur J Endocrinol       Date:  2005-09       Impact factor: 6.664

3.  UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality.

Authors:  Helena M Feldmann; Valeria Golozoubova; Barbara Cannon; Jan Nedergaard
Journal:  Cell Metab       Date:  2009-02       Impact factor: 27.287

4.  Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans.

Authors:  Véronique Ouellet; Sébastien M Labbé; Denis P Blondin; Serge Phoenix; Brigitte Guérin; François Haman; Eric E Turcotte; Denis Richard; André C Carpentier
Journal:  J Clin Invest       Date:  2012-01-24       Impact factor: 14.808

5.  Central resistin enhances renal sympathetic nerve activity via phosphatidylinositol 3-kinase but reduces the activity to brown adipose tissue via extracellular signal-regulated kinase 1/2.

Authors:  S Kosari; J A Rathner; E Badoer
Journal:  J Neuroendocrinol       Date:  2012-11       Impact factor: 3.627

6.  Centrally administered resistin enhances sympathetic nerve activity to the hindlimb but attenuates the activity to brown adipose tissue.

Authors:  S Kosari; J A Rathner; F Chen; S Kosari; E Badoer
Journal:  Endocrinology       Date:  2011-05-17       Impact factor: 4.736

Review 7.  Adipokines and the peripheral and neural control of energy balance.

Authors:  Rexford S Ahima; Mitchell A Lazar
Journal:  Mol Endocrinol       Date:  2008-01-17

8.  Comparative studies of resistin expression and phylogenomics in human and mouse.

Authors:  Rong-Ze Yang; Qing Huang; Aihua Xu; John C McLenithan; Jonathan A Eisen; Alan R Shuldiner; Serhan Alkan; Da-Wei Gong; Jonathan A Eison
Journal:  Biochem Biophys Res Commun       Date:  2003-10-24       Impact factor: 3.575

9.  Role of resistin in cardiac contractility and hypertrophy.

Authors:  Maengjo Kim; Jae Kyun Oh; Susumu Sakata; Iifan Liang; Woojin Park; Roger J Hajjar; Djamel Lebeche
Journal:  J Mol Cell Cardiol       Date:  2008-05-20       Impact factor: 5.000

10.  Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin.

Authors:  Kamal Rahmouni; Curt D Sigmund; William G Haynes; Allyn L Mark
Journal:  Diabetes       Date:  2008-12-09       Impact factor: 9.461
View more
  6 in total

1.  Serum resistin levels are associated with adiposity and insulin sensitivity in obese Hispanic subjects.

Authors:  Adriana Nieva-Vazquez; Ricardo Pérez-Fuentes; Enrique Torres-Rasgado; José G López-López; Jose R Romero
Journal:  Metab Syndr Relat Disord       Date:  2013-11-22       Impact factor: 1.894

2.  Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice.

Authors:  Ingrid W Asterholm; Joseph M Rutkowski; Teppei Fujikawa; You-Ree Cho; Makoto Fukuda; Caroline Tao; Zhao V Wang; Rana K Gupta; Joel K Elmquist; Philipp E Scherer
Journal:  Diabetologia       Date:  2014-03-13       Impact factor: 10.122

Review 3.  The brain and brown fat.

Authors:  Cristina Contreras; Francisco Gonzalez; Johan Fernø; Carlos Diéguez; Kamal Rahmouni; Rubén Nogueiras; Miguel López
Journal:  Ann Med       Date:  2014-06-10       Impact factor: 4.709

Review 4.  Secret talk between adipose tissue and central nervous system via secreted factors-an emerging frontier in the neurodegenerative research.

Authors:  Avinash Parimisetty; Anne-Claire Dorsemans; Rana Awada; Palaniyandi Ravanan; Nicolas Diotel; Christian Lefebvre d'Hellencourt
Journal:  J Neuroinflammation       Date:  2016-03-24       Impact factor: 8.322

Review 5.  Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.

Authors:  Cristina Contreras; Rubén Nogueiras; Carlos Diéguez; Kamal Rahmouni; Miguel López
Journal:  Redox Biol       Date:  2017-04-15       Impact factor: 11.799

Review 6.  Resistin, an Adipokine with Non-Generalized Actions on Sympathetic Nerve Activity.

Authors:  Emilio Badoer; Samin Kosari; Martin J Stebbing
Journal:  Front Physiol       Date:  2015-11-10       Impact factor: 4.566
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.