Literature DB >> 2404337

Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family.

N Itoh1, S Yonehara, J Schreurs, D M Gorman, K Maruyama, A Ishii, I Yahara, K Arai, A Miyajima.   

Abstract

Interleukin-3 (IL-3) binds to its receptor with high and low affinities, induces tyrosine phosphorylation, and promotes the proliferation and differentiation of hematopoietic cells. A binding component of the IL-3 receptor was cloned. Fibroblasts transfected with the complementary DNA bound IL-3 with a low affinity [dissociation constant (Kd) of 17.9 +/- 3.6 nM]. No consensus sequence for a tyrosine kinase was present in the cytoplasmic domain. Thus, additional components are required for a functional high affinity IL-3 receptor. A sequence comparison of the IL-3 receptor with other cytokine receptors (erythropoietin, IL-4, IL-6, and the beta chain IL-2 receptor) revealed a common motif of a distinct receptor gene family.

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Year:  1990        PMID： 2404337     DOI： 10.1126/science.2404337

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  85 in total

1.  Cytokine receptor common beta chain as a potential activator of cytokine withdrawal-induced apoptosis.

Authors:  S F Lee; H M Huang; J R Chao; S Lin; H F Yang-Yen; J J Yen
Journal:  Mol Cell Biol       Date:  1999-11       Impact factor: 4.272

2.  Ly49Q, a member of the Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture.

Authors:  Noriko Toyama-Sorimachi; Yusuke Tsujimura; Mikako Maruya; Atsuko Onoda; Toshiyuki Kubota; Shigeo Koyasu; Kayo Inaba; Hajime Karasuyama
Journal:  Proc Natl Acad Sci U S A       Date:  2004-01-19       Impact factor: 11.205

3.  The erythropoietin receptor transmembrane region is necessary for activation by the Friend spleen focus-forming virus gp55 glycoprotein.

Authors:  L I Zon; J F Moreau; J W Koo; B Mathey-Prevot; A D D'Andrea
Journal:  Mol Cell Biol       Date:  1992-07       Impact factor: 4.272

Review 4.  Cytokine receptors: structure and signal transduction.

Authors:  B M Foxwell; K Barrett; M Feldmann
Journal:  Clin Exp Immunol       Date:  1992-11       Impact factor: 4.330

5.  Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter.

Authors:  C M Pleiman; S D Gimpel; L S Park; H Harada; T Taniguchi; S F Ziegler
Journal:  Mol Cell Biol       Date:  1991-06       Impact factor: 4.272

6.  Differential regulation of early response genes and cell proliferation through the human granulocyte macrophage colony-stimulating factor receptor: selective activation of the c-fos promoter by genistein.

Authors:  S Watanabe; A Muto; T Yokota; A Miyajima; K Arai
Journal:  Mol Biol Cell       Date:  1993-10       Impact factor: 4.138

7.  Characterization of mpl cytoplasmic domain sequences required for myeloproliferative leukemia virus pathogenicity.

Authors:  L Bénit; G Courtois; M Charon; P Varlet; I Dusanter-Fourt; S Gisselbrecht
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103

8.  A human GM-CSF receptor expressed in transgenic mice stimulates proliferation and differentiation of hemopoietic progenitors to all lineages in response to human GM-CSF.

Authors:  I Nishijima; T Nakahata; Y Hirabayashi; T Inoue; H Kurata; A Miyajima; N Hayashi; Y Iwakura; K Arai; T Yokota
Journal:  Mol Biol Cell       Date:  1995-05       Impact factor: 4.138

9.  The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains.

Authors:  A D D'Andrea; A Yoshimura; H Youssoufian; L I Zon; J W Koo; H F Lodish
Journal:  Mol Cell Biol       Date:  1991-04       Impact factor: 4.272

10.  c-fos gene induction by interleukin 2: identification of the critical cytoplasmic regions within the interleukin 2 receptor beta chain.

Authors:  M Hatakeyama; A Kawahara; H Mori; H Shibuya; T Taniguchi
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-15       Impact factor: 11.205
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