PURPOSE: Arteriovenous fistula non-maturation because of a peri-anastomotic venous stenosis is currently a huge clinical problem for which there are no effective therapies. METHODS: In an attempt to further define the cellular pathways involved in this process we have assessed the pattern and intensity of macrophage infiltration at different time points in a pig model of AVF stenosis. RESULTS: Our results demonstrate an early and eccentric pattern of macrophage infiltration at 2d with a rapid disappearance of this infiltrate by 7d. CONCLUSION: We suggest that this early and eccentric macrophage infiltration could play an important role in the pathogenesis of AVF non-maturation.
PURPOSE:Arteriovenous fistula non-maturation because of a peri-anastomotic venous stenosis is currently a huge clinical problem for which there are no effective therapies. METHODS: In an attempt to further define the cellular pathways involved in this process we have assessed the pattern and intensity of macrophage infiltration at different time points in a pig model of AVF stenosis. RESULTS: Our results demonstrate an early and eccentric pattern of macrophage infiltration at 2d with a rapid disappearance of this infiltrate by 7d. CONCLUSION: We suggest that this early and eccentric macrophage infiltration could play an important role in the pathogenesis of AVF non-maturation.
Authors: Taisiya Bezhaeva; ChunYu Wong; Margreet R de Vries; Eric P van der Veer; Carla M A van Alem; Ivo Que; Reshma A Lalai; Anton-Jan van Zonneveld; Joris I Rotmans; Paul H A Quax Journal: Sci Rep Date: 2017-08-31 Impact factor: 4.379