Literature DB >> 24043289

Bone health issues in breast cancer survivors: a Medicare Current Beneficiary Survey (MCBS) study.

Luke J Peppone1, Karen M Mustian, Randy N Rosier, Jennifer K Carroll, Jason Q Purnell, Michelle C Janelsins, Gary R Morrow, Supriya G Mohile.   

Abstract

PURPOSE: Breast cancer treatments (chemotherapy and hormone therapy) can cause a rapid loss in bone mineral density, leading to osteoporosis and fractures later in life. Fortunately, preventative measures (vitamin D, exercise, etc.) can delay bone loss if employed early enough. This study compares the prevalence of osteoporosis and osteoporosis-related discussions with physicians among female breast cancer survivors and females with no cancer history to determine if breast cancer patients are being correctly advised on their high risk of bone loss.
METHODS: The 2003 Medicare Current Beneficiary Survey, a nationally representative sample of 550 women with a breast cancer history and 6,673 women with no cancer history aged ≥65, was used. The first set of dependent variables collected information on bone health (osteoporosis, falls, and fractures). The second set of dependent variables collected information on bone health discussions with their physician. Multivariate logistic regression models were used to evaluate whether breast cancer was independently associated with bone health issues.
RESULTS: After adjustment for confounders, a breast cancer diagnosis was found to be associated with a higher prevalence of an osteoporosis diagnosis over their lifetime (adjusted odds ratio (OR(adj)) = 1.32, 95 % confidence interval (95 % CI) = 1.08-1.61) and falls in the previous year (OR(adj) = 1.23, 95 % CI = 1.01-1.51) compared to respondents without a cancer diagnosis. However, breast cancer respondents were not more likely than respondents without a cancer diagnosis to discuss osteoporosis with their physician (OR(adj) = 1.20, 95 % CI = 0.96-1.50) or be told they are at high risk for osteoporosis (OR(adj) = 1.41, 95 % CI = 0.95-2.10).
CONCLUSIONS: A breast cancer diagnosis was associated with an increased prevalence of osteoporosis and falls. Nevertheless, breast cancer respondents were not more likely to discuss osteoporosis with their physician nor were they more likely to be considered high risk for osteoporosis. Increased dialogue between physician and breast cancer patient pertaining to bone loss is needed.

Entities:  

Mesh:

Year:  2013        PMID: 24043289      PMCID: PMC4049181          DOI: 10.1007/s00520-013-1967-4

Source DB:  PubMed          Journal:  Support Care Cancer        ISSN: 0941-4355            Impact factor:   3.603


  32 in total

1.  Cancer survivorship--United States, 1971-2001.

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Journal:  MMWR Morb Mortal Wkly Rep       Date:  2004-06-25       Impact factor: 17.586

2.  Risk of cancer treatment-associated bone loss and fractures among women with breast cancer receiving aromatase inhibitors.

Authors:  Betty A Mincey; Mei Sheng Duh; Simu K Thomas; Erick Moyneur; Maryna Marynchencko; Simone Peart Boyce; David Mallett; Edith A Perez
Journal:  Clin Breast Cancer       Date:  2006-06       Impact factor: 3.225

Review 3.  Osteoporosis due to cancer treatment: pathogenesis and management.

Authors:  J Pfeilschifter; I J Diel
Journal:  J Clin Oncol       Date:  2000-04       Impact factor: 44.544

4.  Cancer statistics, 2010.

Authors:  Ahmedin Jemal; Rebecca Siegel; Jiaquan Xu; Elizabeth Ward
Journal:  CA Cancer J Clin       Date:  2010-07-07       Impact factor: 508.702

5.  Development and validation of a clinical prediction rule for prolonged nursing home residence after hip fracture.

Authors:  J F Steiner; A M Kramer; T B Eilertsen; J C Kowalsky
Journal:  J Am Geriatr Soc       Date:  1997-12       Impact factor: 5.562

6.  Fracture risk increases after diagnosis of breast or other cancers in postmenopausal women: results from the Women's Health Initiative.

Authors:  Z Chen; M Maricic; A K Aragaki; C Mouton; L Arendell; A M Lopez; T Bassford; R T Chlebowski
Journal:  Osteoporos Int       Date:  2008-09-03       Impact factor: 4.507

Review 7.  Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis.

Authors:  Benjamin M P Tang; Guy D Eslick; Caryl Nowson; Caroline Smith; Alan Bensoussan
Journal:  Lancet       Date:  2007-08-25       Impact factor: 79.321

Review 8.  Cancer treatment-induced bone loss: pathophysiology and clinical perspectives.

Authors:  Adam M Brufsky
Journal:  Oncologist       Date:  2008-02

9.  Effect of anastrozole on bone mineral density: 5-year results from the anastrozole, tamoxifen, alone or in combination trial 18233230.

Authors:  Richard Eastell; Judith E Adams; Robert E Coleman; Anthony Howell; Rosemary A Hannon; Jack Cuzick; John R Mackey; Matthias W Beckmann; Glen Clack
Journal:  J Clin Oncol       Date:  2008-03-01       Impact factor: 44.544

10.  Effects of a structured weight-bearing exercise program on bone metabolism among breast cancer survivors: a feasibility trial.

Authors:  Luke J Peppone; Karen M Mustian; Michelle C Janelsins; Oxana G Palesh; Randy N Rosier; Kenneth M Piazza; Jason Q Purnell; Tom V Darling; Gary R Morrow
Journal:  Clin Breast Cancer       Date:  2010-06       Impact factor: 3.225

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  5 in total

1.  Utilization of bone mineral density testing among breast cancer survivors in British Columbia, Canada.

Authors:  O L Tseng; M G Dawes; J J Spinelli; C C Gotay; M L McBride
Journal:  Osteoporos Int       Date:  2017-10-09       Impact factor: 4.507

Review 2.  Caring for the breast cancer survivor's health and well-being.

Authors:  Petra M Casey; Stephanie S Faubion; Kathy L MacLaughlin; Margaret E Long; Sandhya Pruthi
Journal:  World J Clin Oncol       Date:  2014-10-10

3.  A Preliminary Study on the Efficacy of a Community-Based Physical Activity Intervention on Physical Function-Related Risk Factors for Falls Among Breast Cancer Survivors.

Authors:  C Ellen Lee; Stuart J Warden; Beth Szuck; Y K James Lau
Journal:  Am J Phys Med Rehabil       Date:  2016-08       Impact factor: 2.159

4.  Risk of hospitalisation and death due to bone fractures after breast cancer: a registry-based cohort study.

Authors:  Edoardo Colzani; Mark Clements; Anna L V Johansson; Annelie Liljegren; Wei He; Judith Brand; Jan Adolfsson; Tommy Fornander; Per Hall; Kamila Czene
Journal:  Br J Cancer       Date:  2016-10-04       Impact factor: 7.640

Review 5.  Breast cancer survival among young women: a review of the role of modifiable lifestyle factors.

Authors:  Darren R Brenner; Nigel T Brockton; Joanne Kotsopoulos; Michelle Cotterchio; Beatrice A Boucher; Kerry S Courneya; Julia A Knight; Ivo A Olivotto; May Lynn Quan; Christine M Friedenreich
Journal:  Cancer Causes Control       Date:  2016-03-12       Impact factor: 2.506

  5 in total

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