OBJECTIVES: To determine the prevalence of white matter lesions (WMLs) and infarcts in children with migraine and whether pediatric migraine could be a risk factor for silent ischemic lesions or stroke. METHODS: Prospectively collected data from 1,008 pediatric patients with headache were reviewed. The MRI data were collected and retrospectively reviewed. RESULTS: Of the 926 patients diagnosed with migraine, 375 patients had MRIs and 115 had abnormalities, of which 39 had WMLs. Among them, 24 (6% of migraine) patients had incidental white matter findings without known neurovascular disease, risk factors, or etiologies for WMLs. The prevalence of WMLs is more common in migraine with aura (10%) than without aura (4%) (p = 0.038), but it is not statistically significant compared with controls (4%) (p = 0.119). Deep WMLs are more prevalent than periventricular lesions; these are detected mainly in the frontal and parietal lobes. No lesions appeared to be infarct-like lesions. There was no association between the total lesion load and chronicity or the frequency of migraine. WMLs are nonprogressive. Pediatric migraineurs with aura do not develop stroke, based on the available follow-up data. CONCLUSION: WMLs in pediatric patients with migraine and aura are no more prevalent than in controls. They appear to be benign and are not associated with stroke.
OBJECTIVES: To determine the prevalence of white matter lesions (WMLs) and infarcts in children with migraine and whether pediatric migraine could be a risk factor for silent ischemic lesions or stroke. METHODS: Prospectively collected data from 1,008 pediatric patients with headache were reviewed. The MRI data were collected and retrospectively reviewed. RESULTS: Of the 926 patients diagnosed with migraine, 375 patients had MRIs and 115 had abnormalities, of which 39 had WMLs. Among them, 24 (6% of migraine) patients had incidental white matter findings without known neurovascular disease, risk factors, or etiologies for WMLs. The prevalence of WMLs is more common in migraine with aura (10%) than without aura (4%) (p = 0.038), but it is not statistically significant compared with controls (4%) (p = 0.119). Deep WMLs are more prevalent than periventricular lesions; these are detected mainly in the frontal and parietal lobes. No lesions appeared to be infarct-like lesions. There was no association between the total lesion load and chronicity or the frequency of migraine. WMLs are nonprogressive. Pediatric migraineurs with aura do not develop stroke, based on the available follow-up data. CONCLUSION: WMLs in pediatric patients with migraine and aura are no more prevalent than in controls. They appear to be benign and are not associated with stroke.
Authors: Salvatore Petta; Antonino Tuttolomondo; Cesare Gagliardo; Rita Zafonte; Giuseppe Brancatelli; Daniela Cabibi; Calogero Cammà; Vito Di Marco; Luigi Galvano; Giuseppe La Tona; Anna Licata; Franco Magliozzo; Carlo Maida; Giulio Marchesini; Giovanni Merlino; Massimo Midiri; Gaspare Parrinello; Daniele Torres; Antonio Pinto; Antonio Craxì Journal: Medicine (Baltimore) Date: 2016-04 Impact factor: 1.889
Authors: Naila Makhani; Christine Lebrun; Aksel Siva; David Brassat; Clarisse Carra Dallière; Jérôme de Seze; Wei Du; Françoise Durand Dubief; Orhun Kantarci; Megan Langille; Sona Narula; Jean Pelletier; Juan Ignacio Rojas; Eugene D Shapiro; Robert T Stone; Mar Tintoré; Ugur Uygunoglu; Patrick Vermersch; Evangeline Wassmer; Darin T Okuda; Daniel Pelletier Journal: Neurol Neuroimmunol Neuroinflamm Date: 2017-09-25