| Literature DB >> 24042051 |
Nnenna A Finn1, Danny Eapen, Pankaj Manocha, Hatem Al Kassem, Bernard Lassegue, Nima Ghasemzadeh, Arshed Quyyumi, Charles D Searles.
Abstract
Coronary heart disease (CHD) is characterized by abnormal intercellular communication and circulating microRNAs (miRNAs) are likely involved in this process. Here, we show that CHD was associated with changes in the transport of circulating miRNA, particularly decreased miRNA enrichment in microparticles (MPs). Additionally, MPs from CHD patients were less efficient at transferring miRNA to cultured HUVECs, which correlated with their diminished capacity to bind developmental endothelial locus-1 (Del-1). In summary, CHD was associated with distinct changes in circulating miRNA transport and these changes may contribute to the abnormal intercellular communication that underlies CHD initiation and progression. Published by Elsevier B.V.Entities:
Keywords: AP; Atherosclerosis; CHD; Coronary heart disease; Del-1; Developmental endothelial locus-1; Exo; Intercellular signaling; LP; MP/MPs; MicroRNA; Microparticles; RF; aggregated protein; coronary heart disease; developmental endothelial locus-1; exosomes; lipoprotein; microparticles; risk factor
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Year: 2013 PMID： 24042051 PMCID： PMC3910498 DOI： 10.1016/j.febslet.2013.08.034
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124