| Literature DB >> 24041830 |
Agnieszka Baranowska-Bik1, Jan Kochanowski, Dorota Uchman, Ewa Wolinska-Witort, Malgorzata Kalisz, Lidia Martynska, Boguslawa Baranowska, Wojciech Bik.
Abstract
Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system that leads to demyelination and neurodegeneration. VIP and PACAP are structurally related neuropeptides with neuroprotective and anti-inflammatory activities. To evaluate VIP and PACAP-38 in plasma and CSF in humans in correlation with IL-6, IL-10 and TNFα, we compared 20 MS individuals with 27 healthy controls. In MS, a decrease in PACAP-38 in CSF and a decrease in plasma IL-6 concentration were seen. A positive correlation between plasma VIP and plasma IL-6 was identified. We conclude that VIP and PACAP may influence the course of MS.Entities:
Keywords: IL-10; IL-6; Multiple sclerosis; PACAP; TNFα; VIP
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Year: 2013 PMID： 24041830 DOI： 10.1016/j.jneuroim.2013.08.012
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478