OBJECTIVE: To investigate secular trends in echocardiographically determined left ventricular mass (LVM). DESIGN, SETTING AND PARTICIPANTS: Longitudinal community-based cohort study in Framingham, Massachussetts. LVM was calculated from routine echocardiography in 4320 participants (52% women) of the Framingham offspring cohort at examination cycles 4 (1987-1991), 5 (1991-1995), 6 (1995-1998) and 8 (2005-2008), totalling 13 971 person-observations. MAIN OUTCOME MEASURES: Sex-specific trends in mean LVM (and its components, LV diastolic diameter (LVDD) and LV wall thickness (LVWT)), and LVM indexed to body surface area (BSA). RESULTS: In men, age-adjusted LVM modestly increased from examination 4 to 8 (192 g to 198 g, p-trend=0.0005), whereas, in women it decreased from 147 g at examination 4 to 140 g at examination 8 (p-trend<0.0001). The trend for increasing LVM in men tracked with an increasing LVDD (p-trend=0.0002), whereas the decline in LVM in women was accompanied by a decrease in LVWT (p-trend<0.0001). Indexing LVM to BSA abolished the increasing trend in men (p-trend=0.49), whereas, the decreasing trend in women was maintained. CONCLUSIONS: In our longitudinal analysis of a large community-based sample spanning two decades, we observed sex-related differences in trends in LVM, with a modest increase of LVM in men (likely attributable to increasing body size), but a decrease in women. Additional studies are warranted to elucidate the basis for these sex-related differences.
OBJECTIVE: To investigate secular trends in echocardiographically determined left ventricular mass (LVM). DESIGN, SETTING AND PARTICIPANTS: Longitudinal community-based cohort study in Framingham, Massachussetts. LVM was calculated from routine echocardiography in 4320 participants (52% women) of the Framingham offspring cohort at examination cycles 4 (1987-1991), 5 (1991-1995), 6 (1995-1998) and 8 (2005-2008), totalling 13 971 person-observations. MAIN OUTCOME MEASURES: Sex-specific trends in mean LVM (and its components, LV diastolic diameter (LVDD) and LV wall thickness (LVWT)), and LVM indexed to body surface area (BSA). RESULTS: In men, age-adjusted LVM modestly increased from examination 4 to 8 (192 g to 198 g, p-trend=0.0005), whereas, in women it decreased from 147 g at examination 4 to 140 g at examination 8 (p-trend<0.0001). The trend for increasing LVM in men tracked with an increasing LVDD (p-trend=0.0002), whereas the decline in LVM in women was accompanied by a decrease in LVWT (p-trend<0.0001). Indexing LVM to BSA abolished the increasing trend in men (p-trend=0.49), whereas, the decreasing trend in women was maintained. CONCLUSIONS: In our longitudinal analysis of a large community-based sample spanning two decades, we observed sex-related differences in trends in LVM, with a modest increase of LVM in men (likely attributable to increasing body size), but a decrease in women. Additional studies are warranted to elucidate the basis for these sex-related differences.
Authors: J N Woythaler; S L Singer; O L Kwan; R S Meltzer; B Reubner; W Bommer; A DeMaria Journal: J Am Coll Cardiol Date: 1983-08 Impact factor: 24.094
Authors: J M Gardin; R McClelland; D Kitzman; J A Lima; W Bommer; H S Klopfenstein; N D Wong; V E Smith; J Gottdiener Journal: Am J Cardiol Date: 2001-05-01 Impact factor: 2.778
Authors: Bertram Pitt; Nathaniel Reichek; Roland Willenbrock; Faiez Zannad; Robert A Phillips; Barbara Roniker; Jay Kleiman; Scott Krause; Daniel Burns; Gordon H Williams Journal: Circulation Date: 2003-09-29 Impact factor: 29.690
Authors: Richard B Devereux; Björn Dahlöf; Eva Gerdts; Kurt Boman; Markku S Nieminen; Vasilios Papademetriou; Jens Rokkedal; Katherine E Harris; Jonathan M Edelman; Kristian Wachtell Journal: Circulation Date: 2004-08-23 Impact factor: 29.690
Authors: Aram V Chobanian; George L Bakris; Henry R Black; William C Cushman; Lee A Green; Joseph L Izzo; Daniel W Jones; Barry J Materson; Suzanne Oparil; Jackson T Wright; Edward J Roccella Journal: Hypertension Date: 2003-12-01 Impact factor: 10.190
Authors: Johan Sundström; Lisa Sullivan; Jacob Selhub; Emelia J Benjamin; Ralph B D'Agostino; Paul F Jacques; Irwin H Rosenberg; Daniel Levy; Peter W F Wilson; Ramachandran S Vasan Journal: Eur Heart J Date: 2004-03 Impact factor: 29.983
Authors: Ravi V Shah; Jian Rong; Martin G Larson; Ashish Yeri; Olivia Ziegler; Kahraman Tanriverdi; Venkatesh Murthy; Xiaojun Liu; Chunyang Xiao; Alexander R Pico; Tianxiao Huan; Daniel Levy; Gregory D Lewis; Anthony Rosenzweig; Ramachandran S Vasan; Saumya Das; Jane E Freedman Journal: JAMA Cardiol Date: 2018-09-01 Impact factor: 14.676
Authors: Ravi V Shah; Venkatesh L Murthy; Siddique A Abbasi; John Eng; Colin Wu; Pamela Ouyang; Raymond Y Kwong; Allison Goldfine; David A Bluemke; Joao Lima; Michael Jerosch-Herold Journal: Eur J Prev Cardiol Date: 2014-07-09 Impact factor: 7.804