Literature DB >> 24039168

Metal-based compounds as prospective antileishmanial agents: inhibition of trypanothione reductase by selected gold complexes.

Gianni Colotti1, Andrea Ilari, Annarita Fiorillo, Paola Baiocco, Maria Agostina Cinellu, Laura Maiore, Federica Scaletti, Chiara Gabbiani, Luigi Messori.   

Abstract

Picking a fight with parasites! Trypanothione reductase (TR) is a validated drug target for the development of antileishmanial agents. A group of structurally diverse gold-containing compounds was evaluated in vitro for TR inhibition. A number of compounds exhibited potent activity and deserve further pharmacological evaluation.
Copyright © 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  Leishmania; antiprotozoal agents; gold; inhibitors; trypanothione reductase

Mesh：

Substances：

Year:  2013        PMID： 24039168     DOI： 10.1002/cmdc.201300276

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


  10 in total

1.  The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I).

Authors:  Gustavo Salinas; Wei Gao; Yang Wang; Mariana Bonilla; Long Yu; Andrey Novikov; Veridiana G Virginio; Henrique B Ferreira; Marisol Vieites; Vadim N Gladyshev; Dinorah Gambino; Shaodong Dai
Journal:  Antioxid Redox Signal       Date:  2017-06-26       Impact factor: 8.401

2.  Green chemical synthesis of gold nanoparticles by using Penicillium aculeatum and their scolicidal activity against hydatid cyst protoscolices of Echinococcus granulosus.

Authors:  Hamed Barabadi; Soheila Honary; Milad Ali Mohammadi; Ehsan Ahmadpour; Mohammad Taghi Rahimi; Ahad Alizadeh; Farzaneh Naghibi; Muthupandian Saravanan
Journal:  Environ Sci Pollut Res Int       Date:  2017-01-04       Impact factor: 4.223

3.  Crystal structure and solution characterization of the thioredoxin-2 from Plasmodium falciparum, a constituent of an essential parasitic protein export complex.

Authors:  Mindy Peng; Duilio Cascio; Pascal F Egea
Journal:  Biochem Biophys Res Commun       Date:  2014-12-02       Impact factor: 3.575

4.  Critical Antileishmanial in vitro Effects of Highly Examined Gold Nanoparticles.

Authors:  Muzamil Yaqub Want; Priya Yadav; Rakin Khan; Garima Chouhan; Mohammad Islamuddin; Sheka Yagub Aloyouni; Asoke P Chattopadhyay; Suliman Yousef AlOmar; Farhat Afrin
Journal:  Int J Nanomedicine       Date:  2021-10-28

5.  Activity of Auranofin against Multiple Genotypes of Naegleria fowleri and Its Synergistic Effect with Amphotericin B In Vitro.

Authors:  Jose Ignacio Escrig; Hye Jee Hahn; Anjan Debnath
Journal:  ACS Chem Neurosci       Date:  2020-05-26       Impact factor: 4.418

6.  Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening.

Authors:  Lorenzo Turcano; Esther Torrente; Antonino Missineo; Matteo Andreini; Marina Gramiccia; Trentina Di Muccio; Ilaria Genovese; Annarita Fiorillo; Steven Harper; Alberto Bresciani; Gianni Colotti; Andrea Ilari
Journal:  PLoS Negl Trop Dis       Date:  2018-11-26

7.  Leishmania mexicana Trypanothione Reductase Inhibitors: Computational and Biological Studies.

Authors:  Félix Matadamas-Martínez; Alicia Hernández-Campos; Alfredo Téllez-Valencia; Alejandra Vázquez-Raygoza; Sandra Comparán-Alarcón; Lilián Yépez-Mulia; Rafael Castillo
Journal:  Molecules       Date:  2019-09-04       Impact factor: 4.411

8.  Synthesis, characterization, and mechanistic studies of a gold nanoparticle-amphotericin B covalent conjugate with enhanced antileishmanial efficacy and reduced cytotoxicity.

Authors:  Pushkar Shivam; Saptarshi Mandal; Prakash Kumar; Pragya Prasanna; Saurabh Kumar; Surendra Rajit Prasad; Ashish Kumar; Prolay Das; Vahab Ali; Shubhankar Kumar Singh; Debabrata Mandal
Journal:  Int J Nanomedicine       Date:  2019-08-20

Review 9.  Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases.

Authors:  Theo Battista; Gianni Colotti; Andrea Ilari; Annarita Fiorillo
Journal:  Molecules       Date:  2020-04-21       Impact factor: 4.411

Review 10.  Thioredoxin reductase and its inhibitors.

Authors:  Fulvio Saccoccia; Francesco Angelucci; Giovanna Boumis; Daniela Carotti; Gianni Desiato; Adriana E Miele; Andrea Bellelli
Journal:  Curr Protein Pept Sci       Date:  2014       Impact factor: 3.272
  10 in total

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