Where does it vibrate? Raman spectromicroscopy on a single molecule.

Tip-enhanced Raman spectroscopy combines scanning probe techniques with Raman spectroscopy. Latest developments permit the chemical mapping of individual adsorbed molecules by monitoring molecular vibrations with sub-nanometer resolution. Increased efficiency and reduced photodegradation make this method suitable for studies of adsorbed organic and biomolecules in surface science, catalysis, biochemistry, and related fields.