Literature DB >> 24038828

Biosynthesis of the antimetabolite 6-thioguanine in Erwinia amylovora plays a key role in fire blight pathogenesis.

Sébastien Coyne1, Cornelia Chizzali, Mohammed N A Khalil, Agnieszka Litomska, Klaus Richter, Ludger Beerhues, Christian Hertweck.   

Abstract

Sulfur for fire: The molecular basis for the biosynthesis of the antimetabolite 6-thioguanine (6TG) was unveiled in Erwinia amylovora, the causative agent of fire blight. Bioinformatics, heterologous pathway reconstitution in E. coli, and mutational analyses indicate that the protein YcfA mediates guanine thionation in analogy to 2-thiouridylase. Assays in planta and in cell cultures reveal for the first time a crucial role of 6TG in fire blight pathogenesis.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  Erwinia amylovora; antimetabolites; natural products; phytochemistry; sulfur compounds

Mesh：

Substances：

Year:  2013        PMID： 24038828     DOI： 10.1002/anie.201305595

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  14 in total

Review 1.  Biosynthesis and Chemical Applications of Thioamides.

Authors:  Nilkamal Mahanta; D Miklos Szantai-Kis; E James Petersson; Douglas A Mitchell
Journal:  ACS Chem Biol       Date:  2019-01-30       Impact factor: 5.100

2.  Bioinformatic Expansion and Discovery of Thiopeptide Antibiotics.

Authors:  Christopher J Schwalen; Graham A Hudson; Bryce Kille; Douglas A Mitchell
Journal:  J Am Chem Soc       Date:  2018-07-20       Impact factor: 15.419

3.  Biphenyl 4-Hydroxylases Involved in Aucuparin Biosynthesis in Rowan and Apple Are Cytochrome P450 736A Proteins.

Authors:  Debabrata Sircar; Mariam M Gaid; Cornelia Chizzali; Dennis Reckwell; David Kaufholdt; Till Beuerle; Giovanni A L Broggini; Henryk Flachowsky; Benye Liu; Robert Hänsch; Ludger Beerhues
Journal:  Plant Physiol       Date:  2015-04-10       Impact factor: 8.340

4.  Enzymatic reconstitution of ribosomal peptide backbone thioamidation.

Authors:  Nilkamal Mahanta; Andi Liu; Shihui Dong; Satish K Nair; Douglas A Mitchell
Journal:  Proc Natl Acad Sci U S A       Date:  2018-03-05       Impact factor: 11.205

Review 5.  Mini-Review: Ergothioneine and Ovothiol Biosyntheses, an Unprecedented Trans-Sulfur Strategy in Natural Product Biosynthesis.

Authors:  Nathchar Naowarojna; Ronghai Cheng; Li Chen; Melissa Quill; Meiling Xu; Changming Zhao; Pinghua Liu
Journal:  Biochemistry       Date:  2018-04-06       Impact factor: 3.162

6.  Identification and genetics of 6-thioguanine secreted by Erwinia species and its interference with the growth of other bacteria.

Authors:  A Wensing; M Gernold; S Jock; R Jansen; K Geider
Journal:  Mol Genet Genomics       Date:  2013-12-29       Impact factor: 3.291

7.  The hidden enzymology of bacterial natural product biosynthesis.

Authors:  Thomas A Scott; Jörn Piel
Journal:  Nat Rev Chem       Date:  2019-06-12       Impact factor: 34.035

8.  Expression of Biphenyl Synthase Genes and Formation of Phytoalexin Compounds in Three Fire Blight-Infected Pyrus communis Cultivars.

Authors:  Cornelia Chizzali; Asya K Swiddan; Sahar Abdelaziz; Mariam Gaid; Klaus Richter; Thilo C Fischer; Benye Liu; Ludger Beerhues
Journal:  PLoS One       Date:  2016-07-13       Impact factor: 3.240

9.  Conservation of Erwinia amylovora pathogenicity-relevant genes among Erwinia genomes.

Authors:  Luigimaria Borruso; Marco Salomone-Stagni; Ivan Polsinelli; Armin Otto Schmitt; Stefano Benini
Journal:  Arch Microbiol       Date:  2017-07-10       Impact factor: 2.552

10.  Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in methanogenic and methanotrophic Archaea.

Authors:  Dipti D Nayak; Nilkamal Mahanta; Douglas A Mitchell; William W Metcalf
Journal:  Elife       Date:  2017-09-07       Impact factor: 8.140
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