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Literature DB >> 24038824

Water-soluble polymers coupled with glycopeptide antigens and T-cell epitopes as potential antitumor vaccines.

Lutz Nuhn¹, Sebastian Hartmann, Björn Palitzsch, Bastian Gerlitzki, Edgar Schmitt, Rudolf Zentel, Horst Kunz.

Abstract

Highly decorated: Tumor-associated MUC1 glycopeptide and tetanus toxoid T-cell epitope P2 can be attached to water-soluble poly(N-(2-hydroxypropyl)methacrylamide) carriers by orthogonal ligation techniques. Fully synthetic vaccine A with additional nanostructure-promoting domains induced antibodies that exhibit high affinity to tumor cells.

Entities: Chemical Disease Gene

Keywords: HPMA; MUC1 glycopeptides; T-helper-cell epitope peptides; antitumor vaccines; polymer glycopeptide conjugates

Mesh：

Substances：

Year: 2013 PMID： 24038824 DOI： 10.1002/anie.201304212

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

13 in total

1. Carbohydrate antigen delivery by water soluble copolymers as potential anti-cancer vaccines.

Authors: Qian Qin; Zhaojun Yin; Philip Bentley; Xuefei Huang
Journal: Medchemcomm Date: 2014-08-01 Impact factor: 3.597

2. Design of a MUC1-based tricomponent vaccine adjuvanted with FSL-1 for cancer immunotherapy.

Authors: Mingjing Li; Zhaoyu Wang; Bocheng Yan; Xiaona Yin; Yue Zhao; Fan Yu; Meng Meng; Yonghui Liu; Wei Zhao
Journal: Medchemcomm Date: 2019-07-12 Impact factor: 3.597

Review 3. Practical Considerations, Challenges, and Limitations of Bioconjugation via Azide-Alkyne Cycloaddition.

Authors: Chad J Pickens; Stephanie N Johnson; Melissa M Pressnall; Martin A Leon; Cory J Berkland
Journal: Bioconjug Chem Date: 2018-02-01 Impact factor: 4.774

4. Synthetic linear glycopolymers and their biological applications.

Authors: Qian Qin; Shuyao Lang; Xuefei Huang
Journal: J Carbohydr Chem Date: 2021-05-27 Impact factor: 1.667

5. Well-Defined Mannosylated Polymer for Peptide Vaccine Delivery with Enhanced Antitumor Immunity.

Authors: Shixian Lv; Kefan Song; Albert Yen; David J Peeler; Dinh Chuong Nguyen; Audrey Olshefsky; Meilyn Sylvestre; Selvi Srinivasan; Patrick S Stayton; Suzie H Pun
Journal: Adv Healthc Mater Date: 2021-11-07 Impact factor: 11.092

6. Valency and density matter: Deciphering impacts of immunogen structures on immune responses against a tumor associated carbohydrate antigen using synthetic glycopolymers.

Authors: Qian Qin; Zhaojun Yin; Xuanjun Wu; Karen M Haas; Xuefei Huang
Journal: Biomaterials Date: 2016-06-02 Impact factor: 12.479

Water-soluble polymers coupled with glycopeptide antigens and T-cell epitopes as potential antitumor vaccines.

1. Carbohydrate antigen delivery by water soluble copolymers as potential anti-cancer vaccines.

2. Design of a MUC1-based tricomponent vaccine adjuvanted with FSL-1 for cancer immunotherapy.

Review 3. Practical Considerations, Challenges, and Limitations of Bioconjugation via Azide-Alkyne Cycloaddition.

4. Synthetic linear glycopolymers and their biological applications.

5. Well-Defined Mannosylated Polymer for Peptide Vaccine Delivery with Enhanced Antitumor Immunity.

6. Valency and density matter: Deciphering impacts of immunogen structures on immune responses against a tumor associated carbohydrate antigen using synthetic glycopolymers.

7. Chemical Synthesis of GM2 Glycans, Bioconjugation with Bacteriophage Qβ, and the Induction of Anticancer Antibodies.

Review 8. Immunological Evaluation of Recent MUC1 Glycopeptide Cancer Vaccines.

9. Interleukin-13 peptide vaccine induces protective humoral immunity in murine asthma models.

Review 10. Strategy for Designing a Synthetic Tumor Vaccine: Multi-Component, Multivalency and Antigen Modification.