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Literature DB >> 24038729

Opsin, a structural model for olfactory receptors?

Jung Hee Park¹, Takefumi Morizumi, Yafang Li, Joo Eun Hong, Emil F Pai, Klaus Peter Hofmann, Hui-Woog Choe, Oliver P Ernst.

Abstract

Receptor-ligand interaction: Olfactory receptors (ORs) are G-protein-coupled receptors (GPCRs), which detect signaling molecules such as hormones and odorants. The structure of opsin, the GPCR employed in vision, with a detergent molecule bound deep in its orthosteric ligand-binding pocket provides a template for OR homology modeling, thus enabling investigation of the structural basis of the mechanism of odorant-receptor recognition.

Entities: Gene

Keywords: GPCR; homology modeling; olfactory receptor; protein structures; receptors

Mesh：

Substances：

Year: 2013 PMID： 24038729 DOI： 10.1002/anie.201302374

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

39 in total

Review 1. Structural approaches to understanding retinal proteins needed for vision.

Authors: Tivadar Orban; Beata Jastrzebska; Krzysztof Palczewski
Journal: Curr Opin Cell Biol Date: 2013-11-28 Impact factor: 8.382

Review 2. Microbial and animal rhodopsins: structures, functions, and molecular mechanisms.

Authors: Oliver P Ernst; David T Lodowski; Marcus Elstner; Peter Hegemann; Leonid S Brown; Hideki Kandori
Journal: Chem Rev Date: 2013-12-23 Impact factor: 60.622

3. G protein-coupled receptors: the evolution of structural insight.

Authors: Samantha B Gacasan; Daniel L Baker; Abby L Parrill
Journal: AIMS Biophys Date: 2017-08-21

4. Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11 Protein Pathway and the β-Arrestin Pathway Using Molecular Dynamics Simulations.

Authors: Jérôme Cabana; Brian Holleran; Richard Leduc; Emanuel Escher; Gaétan Guillemette; Pierre Lavigne
Journal: J Biol Chem Date: 2015-05-01 Impact factor: 5.157

5. Conformational selection and equilibrium governs the ability of retinals to bind opsin.

Authors: Christopher T Schafer; David L Farrens
Journal: J Biol Chem Date: 2014-12-01 Impact factor: 5.157

6. Conformational equilibria of light-activated rhodopsin in nanodiscs.

Authors: Ned Van Eps; Lydia N Caro; Takefumi Morizumi; Ana Karin Kusnetzow; Michal Szczepek; Klaus Peter Hofmann; Timothy H Bayburt; Stephen G Sligar; Oliver P Ernst; Wayne L Hubbell
Journal: Proc Natl Acad Sci U S A Date: 2017-04-03 Impact factor: 11.205

Opsin, a structural model for olfactory receptors?

Review 1. Structural approaches to understanding retinal proteins needed for vision.

Review 2. Microbial and animal rhodopsins: structures, functions, and molecular mechanisms.

3. G protein-coupled receptors: the evolution of structural insight.

4. Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11 Protein Pathway and the β-Arrestin Pathway Using Molecular Dynamics Simulations.

5. Conformational selection and equilibrium governs the ability of retinals to bind opsin.

6. Conformational equilibria of light-activated rhodopsin in nanodiscs.

7. Molecular recognition of ketamine by a subset of olfactory G protein-coupled receptors.

8. A benchmark study of loop modeling methods applied to G protein-coupled receptors.

9. In Silico Studies Targeting G-protein Coupled Receptors for Drug Research Against Parkinson's Disease.

Review 10. Constitutively active rhodopsin and retinal disease.