BACKGROUND: Increasing evidence suggests that diabetes mellitus (DM) is associated with increased cancer incidence and mortality. Several mechanisms involved in diabetes, such as promotion of cell proliferation and decreased apoptosis, may foster carcinogenesis. This study investigated the association between DM and cancer incidence and cancer-specific mortality in patients with breast and colorectal carcinoma. METHODS: A meta-analysis of controlled trials, prospective cohort studies and pooled cohort studies published after 2007 was conducted. Embase, PubMed and the Cochrane Library were searched. Summary hazard ratios (HRs) were calculated using a random-effects model. Sensitivity and subgroup analyses were performed to adjust for confounders, mode of DM assessment and follow-up time. RESULTS: Twenty studies were included to investigate the association between DM and breast and colorectal cancer incidence and cancer-specific mortality. The studies predominantly comprised patients with type II DM. The overall HR for breast cancer incidence was 1·23 (95 per cent confidence interval 1·12 to 1·34) and that for colorectal cancer was 1·26 (1·14 to 1·40) in patients with DM compared with those without diabetes. The overall HR was 1·38 (1·20 to 1·58) for breast cancer- and 1·30 (1·15 to 1·47) for colorectal cancer-specific mortality in patients with DM compared with those without diabetes. CONCLUSION: This meta-analysis indicated that DM is a risk factor for breast and colorectal cancer, and for cancer-specific mortality.
BACKGROUND: Increasing evidence suggests that diabetes mellitus (DM) is associated with increased cancer incidence and mortality. Several mechanisms involved in diabetes, such as promotion of cell proliferation and decreased apoptosis, may foster carcinogenesis. This study investigated the association between DM and cancer incidence and cancer-specific mortality in patients with breast and colorectal carcinoma. METHODS: A meta-analysis of controlled trials, prospective cohort studies and pooled cohort studies published after 2007 was conducted. Embase, PubMed and the Cochrane Library were searched. Summary hazard ratios (HRs) were calculated using a random-effects model. Sensitivity and subgroup analyses were performed to adjust for confounders, mode of DM assessment and follow-up time. RESULTS: Twenty studies were included to investigate the association between DM and breast and colorectal cancer incidence and cancer-specific mortality. The studies predominantly comprised patients with type II DM. The overall HR for breast cancer incidence was 1·23 (95 per cent confidence interval 1·12 to 1·34) and that for colorectal cancer was 1·26 (1·14 to 1·40) in patients with DM compared with those without diabetes. The overall HR was 1·38 (1·20 to 1·58) for breast cancer- and 1·30 (1·15 to 1·47) for colorectal cancer-specific mortality in patients with DM compared with those without diabetes. CONCLUSION: This meta-analysis indicated that DM is a risk factor for breast and colorectal cancer, and for cancer-specific mortality.
Authors: Catherine Schairer; Shahinaz M Gadalla; Ruth M Pfeiffer; Steven C Moore; Eric A Engels Journal: Cancer Epidemiol Biomarkers Prev Date: 2017-01-13 Impact factor: 4.254
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Authors: David A Drew; Madeline M Schuck; Marina V Magicheva-Gupta; Kathleen O Stewart; Katherine K Gilpin; Patrick Miller; Melanie P Parziale; Emily N Pond; Oliver Takacsi-Nagy; Dylan C Zerjav; Samantha M Chin; Jennifer Mackinnon Krems; Dana Meixell; Amit D Joshi; Wenjie Ma; Francis P Colizzo; Peter J Carolan; Norman S Nishioka; Kyle Staller; James M Richter; Hamed Khalili; Manish K Gala; John J Garber; Daniel C Chung; Joseph C Yarze; Lawrence Zukerberg; Giovanna Petrucci; Bianca Rocca; Carlo Patrono; Ginger L Milne; Molin Wang; Andrew T Chan Journal: Cancer Prev Res (Phila) Date: 2020-07-27
Authors: Susan Storey; Andrea Cohee; Wambui G Gathirua-Mwangi; Eric Vachon; Patrick Monahan; Julie Otte; Timothy E Stump; David Cella; Victoria Champion Journal: Oncol Nurs Forum Date: 2019-07-01 Impact factor: 2.172
Authors: Catherine R Marinac; Loki Natarajan; Dorothy D Sears; Linda C Gallo; Sheri J Hartman; Elva Arredondo; Ruth E Patterson Journal: Cancer Epidemiol Biomarkers Prev Date: 2015-04-20 Impact factor: 4.254