Literature DB >> 24036680

Functions and roles of a protein-associated factor.

Md Mosharrof Hossain Sarker1, Meng Chu Zhou, Pranela Rameshwar, John A Hanover.   

Abstract

The divergence of protein (Hedgehog) in different organisms remains an unresolved issue to comprehend how the pathway in Hh signaling evolves. Insights into this question can help one identify the key molecules in Hh signaling. This work proposes a protein-associated factor in cells. The development of a non-reductionist theory of cellular functions in medicine is not sufficient. It is necessary to find the parameters with regards to molecules/genes that can elicit functions. This work shows that molecular interactions of gene products can be accomplished by biophysics logic. Defining the protein-associated factors in molecular activities and identifying its roles in molecular transduction are important. A misregulation in molecular switch can account for complex biomolecular consequences. This work shows the potential of the factor on homo-sapiens and unlocks its implications to gene multi-tasking functionality. The associated factor notion should facilitate the medical development in cancer therapeutics.

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Year:  2014        PMID: 24036680      PMCID: PMC6402795          DOI: 10.1007/s12013-013-9743-0

Source DB:  PubMed          Journal:  Cell Biochem Biophys        ISSN: 1085-9195            Impact factor:   2.194


  17 in total

1.  Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.

Authors:  Veronica Palma; Ariel Ruiz i Altaba
Journal:  Development       Date:  2003-12-17       Impact factor: 6.868

Review 2.  Hedgehog signal transduction: recent findings.

Authors:  Kent Nybakken; Norbert Perrimon
Journal:  Curr Opin Genet Dev       Date:  2002-10       Impact factor: 5.578

3.  Overcoming endogenous constraints on neuronal regeneration.

Authors:  Nassir Mokarram; Ravi V Bellamkonda
Journal:  IEEE Trans Biomed Eng       Date:  2010-12-30       Impact factor: 4.538

4.  Cooperative requirement of the Gli proteins in neurogenesis.

Authors:  Vân Nguyen; Ann L Chokas; Barbara Stecca; Ariel Ruiz i Altaba
Journal:  Development       Date:  2005-07       Impact factor: 6.868

5.  Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved.

Authors:  Miao-Hsueh Chen; Christopher W Wilson; Ya-Jun Li; Kelvin King Lo Law; Chi-Sheng Lu; Rhodora Gacayan; Xiaoyun Zhang; Chi-chung Hui; Pao-Tien Chuang
Journal:  Genes Dev       Date:  2009-08-15       Impact factor: 11.361

6.  Growth, hedgehog and the price of GAS.

Authors:  José L Mullor; Ariel Ruiz i Altaba
Journal:  Bioessays       Date:  2002-01       Impact factor: 4.345

7.  Sonic hedgehog controls stem cell behavior in the postnatal and adult brain.

Authors:  Verónica Palma; Daniel A Lim; Nadia Dahmane; Pilar Sánchez; Thomas C Brionne; Claudia D Herzberg; Yorick Gitton; Alan Carleton; Arturo Alvarez-Buylla; Ariel Ruiz i Altaba
Journal:  Development       Date:  2004-12-16       Impact factor: 6.868

8.  Hedgehog regulates smoothened activity by inducing a conformational switch.

Authors:  Yun Zhao; Chao Tong; Jin Jiang
Journal:  Nature       Date:  2007-10-24       Impact factor: 49.962

9.  Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.

Authors:  Kenneth P Olive; Michael A Jacobetz; Christian J Davidson; Aarthi Gopinathan; Dominick McIntyre; Davina Honess; Basetti Madhu; Mae A Goldgraben; Meredith E Caldwell; David Allard; Kristopher K Frese; Gina Denicola; Christine Feig; Chelsea Combs; Stephen P Winter; Heather Ireland-Zecchini; Stefanie Reichelt; William J Howat; Alex Chang; Mousumi Dhara; Lifu Wang; Felix Rückert; Robert Grützmann; Christian Pilarsky; Kamel Izeradjene; Sunil R Hingorani; Pearl Huang; Susan E Davies; William Plunkett; Merrill Egorin; Ralph H Hruban; Nigel Whitebread; Karen McGovern; Julian Adams; Christine Iacobuzio-Donahue; John Griffiths; David A Tuveson
Journal:  Science       Date:  2009-05-21       Impact factor: 47.728

10.  Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process.

Authors:  Rajat Rohatgi; Ljiljana Milenkovic; Ryan B Corcoran; Matthew P Scott
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-13       Impact factor: 11.205

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