| Literature DB >> 24036266 |
Shoichiro Ozaki1, Akinobu Z Suzuki, Peter O Bauer, Etsuko Ebisui, Katsuhiko Mikoshiba.
Abstract
In order to obtain compounds with modified 2-APB activities, we synthesized number of 2-APB analogues and analyzed their inhibitory activities for SOCE. The IC50 of 2-APB for SOCE inhibition is 3 μM while IC50 of some of our 2-APB analogues range 0.1-10 μM. The adducts of amino acids with diphenyl borinic acid have strong inhibitory activities. By using these compounds, we will be able to regulate intracellular Ca(2+) concentration and consequent cellular processes more efficiently than with 2-APB.Entities:
Keywords: 2-APB; 2-APB analogue; Regulator of intracellular Ca(2+) concentration; SOCE
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Year: 2013 PMID： 24036266 DOI： 10.1016/j.bbrc.2013.08.102
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575