Di Wang1, Tie-Jian Jiang, Lan Liao, Jin Huang. 1. Department of Endocrinology, First affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453100, PR China.
Abstract
BACKGROUND: Omentin-1, as a newly discovered adipocytokine, plays an important role in bone metabolism. However, the association between circulating omentin-1 level and bone mineral density (BMD) in Chinese women has never been investigated. METHODS: Serum omentin-1, adiponectin, leptin, bone turnover biochemical markers, BMD were determined in 225 premenopausal women and 285 postmenopausal women. RESULTS: In premenopausal Chinese women, omentin-1 level was significantly higher compared to postmenopausal women. The multiple linear stepwise regression analysis showed that lean mass, omentin-1 and weight were independent predictors of BMD in premenopausal women. Omentin-1 was negatively correlated with bone-specific alkaline phosphatase (BAP) and bone cross-linked N-terminal telopeptides of type I collagen (NTX) in premenopausal women. However the omentin-1 was not the predictor of BMD in postmenopausal women. CONCLUSIONS: Omentin-1 is an independent predictor of BMD in premenopausal Chinese women, and shows a negative correlation with bone turnover biochemical markers. Our results suggest that omentin-1 may exert a negative effect on bone mass by inhibiting bone formation in premenopausal women.
BACKGROUND: Omentin-1, as a newly discovered adipocytokine, plays an important role in bone metabolism. However, the association between circulating omentin-1 level and bone mineral density (BMD) in Chinese women has never been investigated. METHODS: Serum omentin-1, adiponectin, leptin, bone turnover biochemical markers, BMD were determined in 225 premenopausal women and 285 postmenopausal women. RESULTS: In premenopausal Chinese women, omentin-1 level was significantly higher compared to postmenopausal women. The multiple linear stepwise regression analysis showed that lean mass, omentin-1 and weight were independent predictors of BMD in premenopausal women. Omentin-1 was negatively correlated with bone-specific alkaline phosphatase (BAP) and bone cross-linked N-terminal telopeptides of type I collagen (NTX) in premenopausal women. However the omentin-1 was not the predictor of BMD in postmenopausal women. CONCLUSIONS: Omentin-1 is an independent predictor of BMD in premenopausal Chinese women, and shows a negative correlation with bone turnover biochemical markers. Our results suggest that omentin-1 may exert a negative effect on bone mass by inhibiting bone formation in premenopausal women.
Keywords:
BAP; BMD; BMI; Bone mineral density; Chinese women; N-telopeptides of typeIcollagen; NTX; OPG; Omentin-1; PTH; RANKL; body mass index., dual energy X-ray absorptiometry; bone alkaline phosphatase; bone mineral density; osteoprotegerin; parathyroid hormone; receptor activator of the NF-kB ligand
Authors: J Menzel; R Di Giuseppe; R Biemann; K Aleksandrova; O Kuxhaus; C Wittenbecher; A Fritsche; M B Schulze; B Isermann; H Boeing; C Weikert Journal: J Endocrinol Invest Date: 2016-09-10 Impact factor: 4.256