| Literature DB >> 24035008 |
Burçak Vural1, Elçin Sehitoğlu, Filiz Cavuş, Nazlı Yalçınkaya, Hazal Haytural, Melike Küçükerden, Canan Ulusoy, Elif Uğurel, Selin Turan, Leyla Bulut, Recai Türkoğlu, Erkingül Shugaiv, Murat Kürtüncü, Sükrü Atakan, Ali O Güre, Ahmet Gül, Mefkure Eraksoy, Gülşen Akman-Demir, Erdem Tüzün.
Abstract
Efforts for the identification of diagnostic autoantibodies for neuro-Behcet's disease (NBD) have failed. Screening of NBD patients' sera with protein macroarray identified mitochondrial carrier homolog 1 (Mtch1), an apoptosis-related protein, as a potential autoantigen. ELISA studies showed serum Mtch1 antibodies in 68 of 144 BD patients with or without neurological involvement and in 4 of 168 controls corresponding to a sensitivity of 47.2% and specificity of 97.6%. Mtch1 antibody positive NBD patients had more attacks, increased disability and lower serum nucleosome levels. Mtch1 antibody might be involved in pathogenic mechanisms of NBD rather than being a coincidental byproduct of autoinflammation.Entities:
Keywords: Anti-neuronal antibody; Antibody; Autoimmunity; Behçet's disease; Mitochondrial carrier homolog 1; Neuro-Behçet's disease
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Year: 2013 PMID： 24035008 DOI： 10.1016/j.jneuroim.2013.08.007
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478