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Literature DB >> 24034518

Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity.

L O Mosnier¹, J A Fernández, T P Davis, B V Zlokovic, J H Griffin.

Abstract

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2013 PMID： 24034518 PMCID： PMC3850769 DOI： 10.1111/jth.12400

Source DB: PubMed Journal: J Thromb Haemost ISSN： 1538-7836 Impact factor: 5.824

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14 in total

Review 1. The cytoprotective protein C pathway.

Authors: Laurent O Mosnier; Berislav V Zlokovic; John H Griffin
Journal: Blood Date: 2006-11-16 Impact factor: 22.113

2. Alteplase for acute stroke revisited: the first 10 years.

Authors: Patrick D Lyden; Kennedy R Lees; Stephen M Davis
Journal: Lancet Neurol Date: 2006-09 Impact factor: 44.182

Review 3. Regulation of fibrinolysis by thrombin activatable fibrinolysis inhibitor, an unstable carboxypeptidase B that unites the pathways of coagulation and fibrinolysis.

Authors: Laurent O Mosnier; Bonno N Bouma
Journal: Arterioscler Thromb Vasc Biol Date: 2006-09-07 Impact factor: 8.311

4. Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke.

Authors: Patricia D Williams; Berislav V Zlokovic; John H Griffin; Kent E Pryor; Thomas P Davis
Journal: Curr Pharm Des Date: 2012 Impact factor: 3.116

5. Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C.

Authors: Dong Liu; Tong Cheng; Huang Guo; José A Fernández; John H Griffin; Xiaomei Song; Berislav V Zlokovic
Journal: Nat Med Date: 2004-10-31 Impact factor: 53.440

6. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke.

Authors: M Shibata; S R Kumar; A Amar; J A Fernandez; F Hofman; J H Griffin; B V Zlokovic
Journal: Circulation Date: 2001-04-03 Impact factor: 29.690

7. Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions.

Authors: Laurent O Mosnier; Xia V Yang; John H Griffin
Journal: J Biol Chem Date: 2007-09-14 Impact factor: 5.157

8. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective.

Authors: Tong Cheng; Dong Liu; John H Griffin; José A Fernández; Francis Castellino; Elliot D Rosen; Kenji Fukudome; Berislav V Zlokovic
Journal: Nat Med Date: 2003-02-03 Impact factor: 53.440

9. Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity.

Authors: Huang Guo; Itender Singh; Yaoming Wang; Rashid Deane; Theresa Barrett; José A Fernández; Nienwen Chow; John H Griffin; Berislav V Zlokovic
Journal: Eur J Neurosci Date: 2009-03 Impact factor: 3.386

10. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3.

Authors: Huang Guo; Dong Liu; Harris Gelbard; Tong Cheng; Rae Insalaco; José A Fernández; John H Griffin; Berislav V Zlokovic
Journal: Neuron Date: 2004-02-19 Impact factor: 17.173

5 in total

1. Improved coagulation and haemostasis in haemophilia with inhibitors by combinations of superFactor Va and Factor VIIa.

Authors: Vikas Bhat; Annette von Drygalski; Andrew J Gale; John H Griffin; Laurent O Mosnier
Journal: Thromb Haemost Date: 2015-10-15 Impact factor: 5.249

Review 5. Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research.

Authors: Cesar Reis; Onat Akyol; Wing Mann Ho; Camila Araujo; Lei Huang; Richard Applegate; John H Zhang
Journal: Biomed Res Int Date: 2017-02-14 Impact factor: 3.411