Mike R Shaughnessy1, Erik H Hofmeister. 1. Veterinary Teaching Hospital, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
Abstract
OBJECTIVE: The purpose of this systematic review is to summarize the results of studies which have determined the minimum alveolar concentration (MAC) of isoflurane and sevoflurane in domestic cats. STUDY DESIGN: Systematic review. ANIMALS: Cats. METHODS USED: A comprehensive search of research literature was performed without language restriction. The search utilized the Pubmed, Google Scholar, and CAB Abstracts electronic databases using a combination of free text terms 'Minimum alveolar concentration', 'sevoflurane', 'isoflurane', 'anesthetic', 'cat', 'cats' or 'feline'. The search was conducted from November 2010 to June 2012. RESULTS: The MAC for isoflurane ranged from 1.20 ± 0.13% to 2.22 ± 0.35% and the MAC for sevoflurane ranged from 2.5 ± 0.2% to 3.95 ± 0.33%. The average MAC for isoflurane was 1.71 ± 0.07% and for sevoflurane was 3.08 ± 0.4%. CONCLUSIONS & CLINICAL RELEVANCE: The average MAC for isoflurane was 1.71 ± 0.07% and for sevoflurane was 3.08 ± 0.4%. Methodology differed among studies, and particular attention should be paid in the future to appropriate reporting of methods to allow sound conclusions to be made from the results.
OBJECTIVE: The purpose of this systematic review is to summarize the results of studies which have determined the minimum alveolar concentration (MAC) of isoflurane and sevoflurane in domestic cats. STUDY DESIGN: Systematic review. ANIMALS: Cats. METHODS USED: A comprehensive search of research literature was performed without language restriction. The search utilized the Pubmed, Google Scholar, and CAB Abstracts electronic databases using a combination of free text terms 'Minimum alveolar concentration', 'sevoflurane', 'isoflurane', 'anesthetic', 'cat', 'cats' or 'feline'. The search was conducted from November 2010 to June 2012. RESULTS: The MAC for isoflurane ranged from 1.20 ± 0.13% to 2.22 ± 0.35% and the MAC for sevoflurane ranged from 2.5 ± 0.2% to 3.95 ± 0.33%. The average MAC for isoflurane was 1.71 ± 0.07% and for sevoflurane was 3.08 ± 0.4%. CONCLUSIONS & CLINICAL RELEVANCE: The average MAC for isoflurane was 1.71 ± 0.07% and for sevoflurane was 3.08 ± 0.4%. Methodology differed among studies, and particular attention should be paid in the future to appropriate reporting of methods to allow sound conclusions to be made from the results.
Authors: Carlos M Acevedo-Arcique; José A Ibancovichi; Julio R Chavez; Eduardo Gutierrez-Blanco; Rafael Moran-Muñoz; José M Victoria-Mora; Francisco Tendillo-Cortijo; Martín Santos-González; Pedro Sanchez-Aparicio Journal: PLoS One Date: 2014-09-18 Impact factor: 3.240