INTRODUCTION: Ischemia-reperfusion injury (IRI) causes a high rate of delayed graft function (DGF), the most frequent complication in the immediate postoperative period after cadaveric donor kidney transplantation. Herein we evaluated the impact of donor and recipient characteristics on DGF development in terms of the incidence of acute rejection episodes, hospital stay, renal function, and long-term graft and patient survivals. MATERIALS AND METHODS: Between February 1998 and July 2011, 761 patients underwent cadaveric donor kidney transplantations. DGF was defined as the need for dialysis in the first week. Patients were subdivided according to initial graft function as immediate graft function (IGF) or DGF. RESULTS: DGF observed in 241 patients (31.6%) was associated independently with expanded criteria donors, extended cold ischemia time, Karpinsky histological score, and prior dialysis duration both univariate and multivariate analysis. The incidence of acute rejection episodes was 18.1% among the DGF group versus 1.3% in the IGF group (P < .01). DGF significantly reduced both graft and patient survivals at 6, 12, 36, and 60 months. CONCLUSION: DGF was responsible for a longer hospital stay, worse early and long-term renal function, a higher incidence of acute rejection episodes as well as reduced graft and patient survivals.
INTRODUCTION:Ischemia-reperfusion injury (IRI) causes a high rate of delayed graft function (DGF), the most frequent complication in the immediate postoperative period after cadaveric donor kidney transplantation. Herein we evaluated the impact of donor and recipient characteristics on DGF development in terms of the incidence of acute rejection episodes, hospital stay, renal function, and long-term graft and patient survivals. MATERIALS AND METHODS: Between February 1998 and July 2011, 761 patients underwent cadaveric donor kidney transplantations. DGF was defined as the need for dialysis in the first week. Patients were subdivided according to initial graft function as immediate graft function (IGF) or DGF. RESULTS: DGF observed in 241 patients (31.6%) was associated independently with expanded criteria donors, extended cold ischemia time, Karpinsky histological score, and prior dialysis duration both univariate and multivariate analysis. The incidence of acute rejection episodes was 18.1% among the DGF group versus 1.3% in the IGF group (P < .01). DGF significantly reduced both graft and patient survivals at 6, 12, 36, and 60 months. CONCLUSION: DGF was responsible for a longer hospital stay, worse early and long-term renal function, a higher incidence of acute rejection episodes as well as reduced graft and patient survivals.
Authors: Zhi-Shun Wang; Tao Qiu; Xiu-Heng Liu; Jiang-Qiao Zhou; Zhong-Bao Chen; Lei Wang; Long Zhang; Ye Shen; Lu Zhang Journal: Int Urol Nephrol Date: 2015-11-13 Impact factor: 2.370
Authors: Nicholas V Mendez; Yehuda Raveh; Joshua J Livingstone; Gaetano Ciancio; Giselle Guerra; George W Burke Iii; Vadim B Shatz; Fouad G Souki; Linda J Chen; Mahmoud Morsi; Jose M Figueiro; Tony M Ibrahim; Werviston L DeFaria; Ramona Nicolau-Raducu Journal: World J Transplant Date: 2021-04-18
Authors: Chang Ho Seo; Jeong Il Ju; Mi-Hyeong Kim; Kang Woong Jun; Sang-Hyun Ahn; Jeong Kye Hwang; Sang Dong Kim; Sun Cheol Park; Bum Soon Choi; Ji Il Kim; Chul Woo Yang; Yong Soo Kim; In Sung Moon Journal: Ann Surg Treat Res Date: 2015-09-25 Impact factor: 1.859