What do we learn from repeated population analyses?

Population analyses are performed on new and existing drugs. They play an important role in quantifying the time course of drug effects and provide a means of understanding the impact of variability between individuals on dosing requirements. For some drugs there have been several population analyses reported in the literature. It is important to understand how repeated population analyses can value add and what authors and readers can consider when reviewing such analyses. The purpose of this review is to explore what is learnt from repeated population analyses and provide an understanding of how the value-added nature of these analyses can be considered.