| Literature DB >> 2403350 |
M Tomomura1, K Kadomatsu, M Nakamoto, H Muramatsu, H Kondoh, K Imagawa, T Muramatsu.
Abstract
MK is a gene whose expression increases transiently during retinoic acid-induced differentiation of embryonal carcinoma cells. MK polypeptide was secreted by differentiating HM-1 embryonal carcinoma cells and by L-cells transfected with an MK cDNA under the control of the beta-actin promoter and Rous sarcoma virus enhancer. MK polypeptide was found to have heparin binding activity. Conditioned medium of the transfected L-cells promoted growth of PC-12 pheochromocytoma cells. These findings support the view that MK polypeptide is a secreted factor involved in regulation of growth and differentiation.Entities:
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Year: 1990 PMID： 2403350 DOI： 10.1016/0006-291x(90)91189-y
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575