Literature DB >> 2403342

Interaction of the pyruvate dehydrogenase complex from human heart with thiamine pyrophosphate.

S A Ostrovtsova, S A Strumilo.   

Abstract

Preparations of a highly purified pyruvate dehydrogenase complex (PDC) from human heart contain endogenous thiamine pyrophosphate (TPP) in an amount accounting for about 10% of the maximum activity. At pH values of 7.5 and 8.0, the effective Michaelis constants with respect to exogenous TPP for the PDC apoenzyme form were 0.22 microM and 1.8 microM, respectively.

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Year:  1990        PMID: 2403342

Source DB:  PubMed          Journal:  Biomed Biochim Acta        ISSN: 0232-766X


  1 in total

1.  Thiamine pyrophosphokinase deficiency causes a Leigh Disease like phenotype in a sibling pair: identification through whole exome sequencing and management strategies.

Authors:  Jamie L Fraser; Adeline Vanderver; Sandra Yang; Taeun Chang; Laura Cramp; Gilbert Vezina; Uta Lichter-Konecki; Kristina P Cusmano-Ozog; Patroula Smpokou; Kimberly A Chapman; Dina J Zand
Journal:  Mol Genet Metab Rep       Date:  2014-02-11
  1 in total

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