Literature DB >> 24030897

A synthetic riboswitch that operates using a rationally designed ligand-RNA pair.

Chikara Dohno1, Izumi Kohyama, Maki Kimura, Masaki Hagihara, Kazuhiko Nakatani.   

Abstract

The construction of an artificial riboswitch is based on a ligand-RNA pair without any molecular biology-based selection processes. The ligand selectively and significantly stabilized an RNA duplex containing an r(XGG)/r(XGG) sequence (X=U, A, G). The integration of the ligand-binding sequences into the 5'-untranslated region of mRNA provided an artificial riboswitch that was responsive to Z-NCTS.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords:  RNA-binding ligand; naphthyridine; riboswitches; synthetic ligands; translational regulation

Mesh：

Substances：

Year:  2013        PMID： 24030897     DOI： 10.1002/anie.201303370

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  6 in total

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Authors:  Stephanie A Barros; Ina Yoon; David M Chenoweth
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2.  Automated physics-based design of synthetic riboswitches from diverse RNA aptamers.

Authors:  Amin Espah Borujeni; Dennis M Mishler; Jingzhi Wang; Walker Huso; Howard M Salis
Journal:  Nucleic Acids Res       Date:  2015-11-30       Impact factor: 16.971

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Authors:  Eric I Sun; Dmitry A Rodionov
Journal:  Biochim Biophys Acta       Date:  2014-02-28

Review 4.  Pharmaceutical Applications of Molecular Tweezers, Clefts and Clips.

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Journal:  Molecules       Date:  2019-05-09       Impact factor: 4.411

5.  Rational guide RNA engineering for small-molecule control of CRISPR/Cas9 and gene editing.

Authors:  Xingyu Liu; Wei Xiong; Qianqian Qi; Yutong Zhang; Huimin Ji; Shuangyu Cui; Jing An; Xiaoming Sun; Hao Yin; Tian Tian; Xiang Zhou
Journal:  Nucleic Acids Res       Date:  2022-04-21       Impact factor: 19.160

6.  Premature translation termination mediated non-ER stress induced ATF6 activation by a ligand-dependent ribosomal frameshifting circuit.

Authors:  Hsiu-Ting Hsu; Asako Murata; Chikara Dohno; Kazuhiko Nakatani; KungYao Chang
Journal:  Nucleic Acids Res       Date:  2022-05-20       Impact factor: 19.160
  6 in total

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