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Literature DB >> 24028951

Neuronal development: SAD kinases make happy axons.

Lei Xing¹, Jason M Newbern, William D Snider.

Abstract

The polarity proteins LKB1 and SAD-A/B are key regulators of axon specification in the developing cerebral cortex. Recent studies now show that this mechanism cannot be generalized to other classes of neurons: instead, SAD-A/B functions downstream of neurotrophin signaling in sensory neurons to mediate a later stage of axon development - arborization in the target field.

Entities: Chemical Disease Gene Species

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Year: 2013 PMID： 24028951 PMCID： PMC3947747 DOI： 10.1016/j.cub.2013.07.073

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

14 in total

1. SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release.

Authors: Eiji Inoue; Sumiko Mochida; Hiroshi Takagi; Susumu Higa; Maki Deguchi-Tawarada; Etsuko Takao-Rikitsu; Marie Inoue; Ikuko Yao; Kosei Takeuchi; Isao Kitajima; Mitsutoshi Setou; Toshihisa Ohtsuka; Yoshimi Takai
Journal: Neuron Date: 2006-04-20 Impact factor: 17.173

2. Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents.

Authors: Tushar D Patel; Ina Kramer; Jan Kucera; Vera Niederkofler; Thomas M Jessell; Silvia Arber; William D Snider
Journal: Neuron Date: 2003-05-08 Impact factor: 17.173

3. LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons.

Authors: Anthony P Barnes; Brendan N Lilley; Y Albert Pan; Lisa J Plummer; Ashton W Powell; Alexander N Raines; Joshua R Sanes; Franck Polleux
Journal: Cell Date: 2007-05-04 Impact factor: 41.582

4. SAD kinases sculpt axonal arbors of sensory neurons through long- and short-term responses to neurotrophin signals.

Authors: Brendan N Lilley; Y Albert Pan; Joshua R Sanes
Journal: Neuron Date: 2013-06-20 Impact factor: 17.173

5. The SAD-1 kinase regulates presynaptic vesicle clustering and axon termination.

Authors: J G Crump; M Zhen; Y Jin; C I Bargmann
Journal: Neuron Date: 2001-01 Impact factor: 17.173

6. Mammalian SAD kinases are required for neuronal polarization.

Authors: Masashi Kishi; Y Albert Pan; Justin Gage Crump; Joshua R Sanes
Journal: Science Date: 2005-02-11 Impact factor: 47.728

7. Introduction of a neurotrophin-3 transgene into muscle selectively rescues proprioceptive neurons in mice lacking endogenous neurotrophin-3.

Authors: D E Wright; L Zhou; J Kucera; W D Snider
Journal: Neuron Date: 1997-09 Impact factor: 17.173

Neuronal development: SAD kinases make happy axons.

1. SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release.

2. Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents.

3. LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons.

4. SAD kinases sculpt axonal arbors of sensory neurons through long- and short-term responses to neurotrophin signals.

5. The SAD-1 kinase regulates presynaptic vesicle clustering and axon termination.

6. Mammalian SAD kinases are required for neuronal polarization.

7. Introduction of a neurotrophin-3 transgene into muscle selectively rescues proprioceptive neurons in mice lacking endogenous neurotrophin-3.

8. LKB1/STRAD promotes axon initiation during neuronal polarization.

9. Neurotrophins support the development of diverse sensory axon morphologies.

10. Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo.

1. Mitochondria coordinate sites of axon branching through localized intra-axonal protein synthesis.