Literature DB >> 24027320

Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist.

Daniela Niemeyer1, Thomas Zillinger, Doreen Muth, Florian Zielecki, Gabor Horvath, Tasnim Suliman, Winfried Barchet, Friedemann Weber, Christian Drosten, Marcel A Müller.   

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory infection with as yet unclear epidemiology. We previously showed that MERS-CoV counteracts parts of the innate immune response in human bronchiolar cells. Here we analyzed accessory proteins 3, 4a, 4b, and 5 for their abilities to inhibit the type I interferon response. Accessory protein 4a was found to block interferon induction at the level of melanoma differentiation-associated protein 5 (MDA5) activation presumably by direct interaction with double-stranded RNA.

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Year:  2013        PMID： 24027320      PMCID： PMC3807936          DOI： 10.1128/JVI.01845-13

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  40 in total

1.  Characterization of a novel coronavirus associated with severe acute respiratory syndrome.

Authors:  Paul A Rota; M Steven Oberste; Stephan S Monroe; W Allan Nix; Ray Campagnoli; Joseph P Icenogle; Silvia Peñaranda; Bettina Bankamp; Kaija Maher; Min-Hsin Chen; Suxiong Tong; Azaibi Tamin; Luis Lowe; Michael Frace; Joseph L DeRisi; Qi Chen; David Wang; Dean D Erdman; Teresa C T Peret; Cara Burns; Thomas G Ksiazek; Pierre E Rollin; Anthony Sanchez; Stephanie Liffick; Brian Holloway; Josef Limor; Karen McCaustland; Melissa Olsen-Rasmussen; Ron Fouchier; Stephan Günther; Albert D M E Osterhaus; Christian Drosten; Mark A Pallansch; Larry J Anderson; William J Bellini
Journal:  Science       Date:  2003-05-01       Impact factor: 47.728

2.  Identification of a novel coronavirus in patients with severe acute respiratory syndrome.

Authors:  Christian Drosten; Stephan Günther; Wolfgang Preiser; Sylvie van der Werf; Hans-Reinhard Brodt; Stephan Becker; Holger Rabenau; Marcus Panning; Larissa Kolesnikova; Ron A M Fouchier; Annemarie Berger; Ana-Maria Burguière; Jindrich Cinatl; Markus Eickmann; Nicolas Escriou; Klaus Grywna; Stefanie Kramme; Jean-Claude Manuguerra; Stefanie Müller; Volker Rickerts; Martin Stürmer; Simon Vieth; Hans-Dieter Klenk; Albert D M E Osterhaus; Herbert Schmitz; Hans Wilhelm Doerr
Journal:  N Engl J Med       Date:  2003-04-10       Impact factor: 91.245

3.  Inhibition of alpha/beta interferon signaling by the NS4B protein of flaviviruses.

Authors:  Jorge L Muñoz-Jordán; Maudry Laurent-Rolle; Joseph Ashour; Luis Martínez-Sobrido; Mundrigi Ashok; W Ian Lipkin; Adolfo García-Sastre
Journal:  J Virol       Date:  2005-07       Impact factor: 5.103

4.  Predicting subcellular localization of proteins based on their N-terminal amino acid sequence.

Authors:  O Emanuelsson; H Nielsen; S Brunak; G von Heijne
Journal:  J Mol Biol       Date:  2000-07-21       Impact factor: 5.469

5.  Identification of the rabies virus alpha/beta interferon antagonist: phosphoprotein P interferes with phosphorylation of interferon regulatory factor 3.

Authors:  Krzysztof Brzózka; Stefan Finke; Karl-Klaus Conzelmann
Journal:  J Virol       Date:  2005-06       Impact factor: 5.103

6.  NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcription.

Authors:  Agnès Billecocq; Martin Spiegel; Pierre Vialat; Alain Kohl; Friedemann Weber; Michèle Bouloy; Otto Haller
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

7.  Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to those of severe acute respiratory syndrome coronavirus.

Authors:  Florian Zielecki; Michaela Weber; Markus Eickmann; Larissa Spiegelberg; Ali Moh Zaki; Mikhail Matrosovich; Stephan Becker; Friedemann Weber
Journal:  J Virol       Date:  2013-02-28       Impact factor: 5.103

8.  The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3.

Authors:  Christopher F Basler; Andrea Mikulasova; Luis Martinez-Sobrido; Jason Paragas; Elke Mühlberger; Mike Bray; Hans-Dieter Klenk; Peter Palese; Adolfo García-Sastre
Journal:  J Virol       Date:  2003-07       Impact factor: 5.103

Review 9.  The interferon response circuit: induction and suppression by pathogenic viruses.

Authors:  Otto Haller; Georg Kochs; Friedemann Weber
Journal:  Virology       Date:  2006-01-05       Impact factor: 3.616

Review 10.  Immunopathogenesis of coronavirus infections: implications for SARS.

Authors:  Stanley Perlman; Ajai A Dandekar
Journal:  Nat Rev Immunol       Date:  2005-12       Impact factor: 53.106
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  126 in total

1.  The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination.

Authors:  Yong Hu; Wei Li; Ting Gao; Yan Cui; Yanwen Jin; Ping Li; Qingjun Ma; Xuan Liu; Cheng Cao
Journal:  J Virol       Date:  2017-03-29       Impact factor: 5.103

2.  Inhibition of Stress Granule Formation by Middle East Respiratory Syndrome Coronavirus 4a Accessory Protein Facilitates Viral Translation, Leading to Efficient Virus Replication.

Authors:  Keisuke Nakagawa; Krishna Narayanan; Masami Wada; Shinji Makino
Journal:  J Virol       Date:  2018-09-26       Impact factor: 5.103

3.  The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling.

Authors:  Krystal L Matthews; Christopher M Coleman; Yvonne van der Meer; Eric J Snijder; Matthew B Frieman
Journal:  J Gen Virol       Date:  2014-01-17       Impact factor: 3.891

4.  Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages.

Authors:  Xufang Deng; Matthew Hackbart; Robert C Mettelman; Amornrat O'Brien; Anna M Mielech; Guanghui Yi; C Cheng Kao; Susan C Baker
Journal:  Proc Natl Acad Sci U S A       Date:  2017-05-08       Impact factor: 11.205

Review 5.  Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease.

Authors:  Jasper F W Chan; Susanna K P Lau; Kelvin K W To; Vincent C C Cheng; Patrick C Y Woo; Kwok-Yung Yuen
Journal:  Clin Microbiol Rev       Date:  2015-04       Impact factor: 26.132

6.  Middle East Respiratory Syndrome Coronavirus Nucleocapsid Protein Suppresses Type I and Type III Interferon Induction by Targeting RIG-I Signaling.

Authors:  Chi-You Chang; Helene Minyi Liu; Ming-Fu Chang; Shin C Chang
Journal:  J Virol       Date:  2020-06-16       Impact factor: 5.103

7.  Middle east respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response.

Authors:  Kam-Leung Siu; Man Lung Yeung; Kin-Hang Kok; Kit-San Yuen; Chun Kew; Pak-Yin Lui; Chi-Ping Chan; Herman Tse; Patrick C Y Woo; Kwok-Yung Yuen; Dong-Yan Jin
Journal:  J Virol       Date:  2014-02-12       Impact factor: 5.103

8.  Rooting the phylogenetic tree of middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African bat.

Authors:  Victor Max Corman; Ndapewa Laudika Ithete; Leigh Rosanne Richards; M Corrie Schoeman; Wolfgang Preiser; Christian Drosten; Jan Felix Drexler
Journal:  J Virol       Date:  2014-07-16       Impact factor: 5.103

9.  Porcine Deltacoronavirus Accessory Protein NS6 Antagonizes Interferon Beta Production by Interfering with the Binding of RIG-I/MDA5 to Double-Stranded RNA.

Authors:  Puxian Fang; Liurong Fang; Jie Ren; Yingying Hong; Xiaorong Liu; Yunyang Zhao; Dang Wang; Guiqing Peng; Shaobo Xiao
Journal:  J Virol       Date:  2018-07-17       Impact factor: 5.103

Review 10.  COVID-19: Complement, Coagulation, and Collateral Damage.

Authors:  Martin W Lo; Claudia Kemper; Trent M Woodruff
Journal:  J Immunol       Date:  2020-07-22       Impact factor: 5.422
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