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Literature DB >> 24027317

Kaposi's sarcoma-associated herpesvirus K7 modulates Rubicon-mediated inhibition of autophagosome maturation.

Qiming Liang¹, Brian Chang, Kevin F Brulois, Kamilah Castro, Chan-Ki Min, Mary A Rodgers, Mude Shi, Jianning Ge, Pinghui Feng, Byung-Ha Oh, Jae U Jung.

Abstract

Autophagy is an important innate safeguard mechanism for protecting an organism against invasion by pathogens. We have previously discovered that Kaposi's sarcoma-associated herpesvirus (KSHV) evades this host defense through tight suppression of autophagy by targeting multiple steps of autophagy signal transduction. Here, we report that KSHV K7 protein interacts with Rubicon autophagy protein and inhibits the autophagosome maturation step by blocking Vps34 enzymatic activity, further highlighting how KSHV deregulates autophagy-mediated host immunity for its life cycle.

Entities: Gene Species

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Year: 2013 PMID： 24027317 PMCID： PMC3807930 DOI： 10.1128/JVI.01898-13

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

27 in total

1. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Authors: Y Kabeya; N Mizushima; T Ueno; A Yamamoto; T Kirisako; T Noda; E Kominami; Y Ohsumi; T Yoshimori
Journal: EMBO J Date: 2000-11-01 Impact factor: 11.598

2. Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis.

Authors: Pinghui Feng; Junsoo Park; Bok-Soo Lee; Sun-Hwa Lee; Richard J Bram; Jae U Jung
Journal: J Virol Date: 2002-11 Impact factor: 5.103

3. The molecular machinery of autophagy: unanswered questions.

Authors: Daniel J Klionsky
Journal: J Cell Sci Date: 2005-01-01 Impact factor: 5.285

4. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.

Authors: Sophie Pattingre; Amina Tassa; Xueping Qu; Rita Garuti; Xiao Huan Liang; Noboru Mizushima; Milton Packer; Michael D Schneider; Beth Levine
Journal: Cell Date: 2005-09-23 Impact factor: 41.582

5. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG.

Authors: Chengyu Liang; Pinghui Feng; Bonsu Ku; Iris Dotan; Dan Canaani; Byung-Ha Oh; Jae U Jung
Journal: Nat Cell Biol Date: 2006-06-25 Impact factor: 28.824

Review 6. Downregulation of autophagy by herpesvirus Bcl-2 homologs.

Authors: Chengyu Liang; Xiaofei E; Jae U Jung
Journal: Autophagy Date: 2007-10-29 Impact factor: 16.016

7. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3.

Authors: Shunsuke Kimura; Takeshi Noda; Tamotsu Yoshimori
Journal: Autophagy Date: 2007-05-21 Impact factor: 16.016

Review 8. Regulation where autophagy intersects the inflammasome.

Authors: Mary A Rodgers; James W Bowman; Qiming Liang; Jae U Jung
Journal: Antioxid Redox Signal Date: 2013-07-31 Impact factor: 8.401

9. Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.

Authors: Hsei-Wei Wang; Tyson V Sharp; Andrew Koumi; Georgy Koentges; Chris Boshoff
Journal: EMBO J Date: 2002-06-03 Impact factor: 11.598

Review 10. Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 and lymphoproliferative disorders.

Authors: M-Q Du; C M Bacon; P G Isaacson
Journal: J Clin Pathol Date: 2007-12 Impact factor: 3.411

42 in total

Review 1. Novel functions of viral anti-apoptotic factors.

Authors: Chengyu Liang; Byung-Ha Oh; Jae U Jung
Journal: Nat Rev Microbiol Date: 2014-11-03 Impact factor: 60.633

2. Epstein-barr virus blocks the autophagic flux and appropriates the autophagic machinery to enhance viral replication.

Authors: Marisa Granato; Roberta Santarelli; Antonella Farina; Roberta Gonnella; Lavinia Vittoria Lotti; Alberto Faggioni; Mara Cirone
Journal: J Virol Date: 2014-08-20 Impact factor: 5.103

3. KSHV reduces autophagy in THP-1 cells and in differentiating monocytes by decreasing CAST/calpastatin and ATG5 expression.

Authors: R Santarelli; M Granato; G Pentassuglia; V Lacconi; M S Gilardini Montani; R Gonnella; M Tafani; M R Torrisi; A Faggioni; M Cirone
Journal: Autophagy Date: 2016-10-07 Impact factor: 16.016

4. Identification of the Essential Role of Viral Bcl-2 for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication.

Authors: Qiming Liang; Brian Chang; Patrick Lee; Kevin F Brulois; Jianning Ge; Mude Shi; Mary A Rodgers; Pinghui Feng; Byung-Ha Oh; Chengyu Liang; Jae U Jung
Journal: J Virol Date: 2015-03-04 Impact factor: 5.103

5. Novel Role of vBcl2 in the Virion Assembly of Kaposi's Sarcoma-Associated Herpesvirus.

Authors: Qiming Liang; Dahai Wei; Brian Chung; Kevin F Brulois; Changrun Guo; Shupeng Dong; Shou-Jiang Gao; Pinghui Feng; Chengyu Liang; Jae U Jung
Journal: J Virol Date: 2018-01-30 Impact factor: 5.103

6. BECLIN 1-VPS34 COMPLEX ARCHITECTURE: UNDERSTANDING THE NUTS AND BOLTS OF THERAPEUTIC TARGETS.

Authors: Deanna H Morris; Calvin K Yip; Yi Shi; Brian T Chait; Qing Jun Wang
Journal: Front Biol (Beijing) Date: 2015-11-04

Review 7. Rubicon: LC3-associated phagocytosis and beyond.

Authors: Sing-Wai Wong; Payel Sil; Jennifer Martinez
Journal: FEBS J Date: 2017-12-29 Impact factor: 5.542

8. Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses.

Authors: Qiming Liang; Gil Ju Seo; Youn Jung Choi; Mi-Jeong Kwak; Jianning Ge; Mary A Rodgers; Mude Shi; Benjamin J Leslie; Karl-Peter Hopfner; Taekjip Ha; Byung-Ha Oh; Jae U Jung
Journal: Cell Host Microbe Date: 2014-02-12 Impact factor: 21.023

9. Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy.

Authors: Qiming Liang; Zhifei Luo; Jianxiong Zeng; Weiqiang Chen; Suan-Sin Foo; Shin-Ae Lee; Jianning Ge; Su Wang; Steven A Goldman; Berislav V Zlokovic; Zhen Zhao; Jae U Jung
Journal: Cell Stem Cell Date: 2016-08-11 Impact factor: 24.633

Review 10. Interplay between Kaposi's sarcoma-associated herpesvirus and the innate immune system.

Authors: Kevin Brulois; Jae U Jung
Journal: Cytokine Growth Factor Rev Date: 2014-06-21 Impact factor: 7.638