Literature DB >> 24026422

Genetic interactions found between calcium channel genes modulate amyloid load measured by positron emission tomography.

Mary Ellen I Koran1, Timothy J Hohman, Tricia A Thornton-Wells.   

Abstract

Late-onset Alzheimer's disease (LOAD) is known to have a complex, oligogenic etiology, with considerable genetic heterogeneity. We investigated the influence of genetic interactions between genes in the Alzheimer's disease (AD) pathway on amyloid-beta (Aβ) deposition as measured by PiB or AV-45 ligand positron emission tomography (PET) to aid in understanding LOAD's genetic etiology. Subsets of the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohorts were used for discovery and for two independent validation analyses. A significant interaction between RYR3 and CACNA1C was confirmed in all three of the independent ADNI datasets. Both genes encode calcium channels expressed in the brain. The results shown here support previous animal studies implicating interactions between these calcium channels in amyloidogenesis and suggest that the pathological cascade of this disease may be modified by interactions in the amyloid-calcium axis. Future work focusing on the mechanisms of such relationships may inform targets for clinical intervention.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 24026422      PMCID： PMC4045094          DOI： 10.1007/s00439-013-1354-8

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  44 in total

1.  Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.

Authors:  Reisa A Sperling; Paul S Aisen; Laurel A Beckett; David A Bennett; Suzanne Craft; Anne M Fagan; Takeshi Iwatsubo; Clifford R Jack; Jeffrey Kaye; Thomas J Montine; Denise C Park; Eric M Reiman; Christopher C Rowe; Eric Siemers; Yaakov Stern; Kristine Yaffe; Maria C Carrillo; Bill Thies; Marcelle Morrison-Bogorad; Molly V Wagster; Creighton H Phelps
Journal:  Alzheimers Dement       Date:  2011-04-21       Impact factor: 21.566

2.  The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.

Authors:  Marilyn S Albert; Steven T DeKosky; Dennis Dickson; Bruno Dubois; Howard H Feldman; Nick C Fox; Anthony Gamst; David M Holtzman; William J Jagust; Ronald C Petersen; Peter J Snyder; Maria C Carrillo; Bill Thies; Creighton H Phelps
Journal:  Alzheimers Dement       Date:  2011-04-21       Impact factor: 21.566

3.  Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.

Authors:  Bénédicte Oulès; Dolores Del Prete; Barbara Greco; Xuexin Zhang; Inger Lauritzen; Jean Sevalle; Sebastien Moreno; Patrizia Paterlini-Bréchot; Mohamed Trebak; Frédéric Checler; Fabio Benfenati; Mounia Chami
Journal:  J Neurosci       Date:  2012-08-22       Impact factor: 6.167

Review 4.  FreeSurfer.

Authors:  Bruce Fischl
Journal:  Neuroimage       Date:  2012-01-10       Impact factor: 6.556

5.  Epistasis between intracellular cholesterol trafficking-related genes (NPC1 and ABCA1) and Alzheimer's disease risk.

Authors:  Eloy Rodríguez-Rodríguez; José Luis Vázquez-Higuera; Pascual Sánchez-Juan; Ignacio Mateo; Ana Pozueta; Ana Martínez-García; Ana Frank; Fernando Valdivieso; José Berciano; María J Bullido; Onofre Combarros
Journal:  J Alzheimers Dis       Date:  2010       Impact factor: 4.472

6.  L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease.

Authors:  Thimmappa S Anekonda; Joseph F Quinn; Christopher Harris; Kate Frahler; Teri L Wadsworth; Randall L Woltjer
Journal:  Neurobiol Dis       Date:  2010-09-09       Impact factor: 5.996

7.  Calcium ions promote formation of amyloid β-peptide (1-40) oligomers causally implicated in neuronal toxicity of Alzheimer's disease.

Authors:  Anna Itkin; Vincent Dupres; Yves F Dufrêne; Burkhard Bechinger; Jean-Marie Ruysschaert; Vincent Raussens
Journal:  PLoS One       Date:  2011-03-28       Impact factor: 3.240

8.  Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Authors:  Adam C Naj; Gyungah Jun; Gary W Beecham; Li-San Wang; Badri Narayan Vardarajan; Jacqueline Buros; Paul J Gallins; Joseph D Buxbaum; Gail P Jarvik; Paul K Crane; Eric B Larson; Thomas D Bird; Bradley F Boeve; Neill R Graff-Radford; Philip L De Jager; Denis Evans; Julie A Schneider; Minerva M Carrasquillo; Nilufer Ertekin-Taner; Steven G Younkin; Carlos Cruchaga; John S K Kauwe; Petra Nowotny; Patricia Kramer; John Hardy; Matthew J Huentelman; Amanda J Myers; Michael M Barmada; F Yesim Demirci; Clinton T Baldwin; Robert C Green; Ekaterina Rogaeva; Peter St George-Hyslop; Steven E Arnold; Robert Barber; Thomas Beach; Eileen H Bigio; James D Bowen; Adam Boxer; James R Burke; Nigel J Cairns; Chris S Carlson; Regina M Carney; Steven L Carroll; Helena C Chui; David G Clark; Jason Corneveaux; Carl W Cotman; Jeffrey L Cummings; Charles DeCarli; Steven T DeKosky; Ramon Diaz-Arrastia; Malcolm Dick; Dennis W Dickson; William G Ellis; Kelley M Faber; Kenneth B Fallon; Martin R Farlow; Steven Ferris; Matthew P Frosch; Douglas R Galasko; Mary Ganguli; Marla Gearing; Daniel H Geschwind; Bernardino Ghetti; John R Gilbert; Sid Gilman; Bruno Giordani; Jonathan D Glass; John H Growdon; Ronald L Hamilton; Lindy E Harrell; Elizabeth Head; Lawrence S Honig; Christine M Hulette; Bradley T Hyman; Gregory A Jicha; Lee-Way Jin; Nancy Johnson; Jason Karlawish; Anna Karydas; Jeffrey A Kaye; Ronald Kim; Edward H Koo; Neil W Kowall; James J Lah; Allan I Levey; Andrew P Lieberman; Oscar L Lopez; Wendy J Mack; Daniel C Marson; Frank Martiniuk; Deborah C Mash; Eliezer Masliah; Wayne C McCormick; Susan M McCurry; Andrew N McDavid; Ann C McKee; Marsel Mesulam; Bruce L Miller; Carol A Miller; Joshua W Miller; Joseph E Parisi; Daniel P Perl; Elaine Peskind; Ronald C Petersen; Wayne W Poon; Joseph F Quinn; Ruchita A Rajbhandary; Murray Raskind; Barry Reisberg; John M Ringman; Erik D Roberson; Roger N Rosenberg; Mary Sano; Lon S Schneider; William Seeley; Michael L Shelanski; Michael A Slifer; Charles D Smith; Joshua A Sonnen; Salvatore Spina; Robert A Stern; Rudolph E Tanzi; John Q Trojanowski; Juan C Troncoso; Vivianna M Van Deerlin; Harry V Vinters; Jean Paul Vonsattel; Sandra Weintraub; Kathleen A Welsh-Bohmer; Jennifer Williamson; Randall L Woltjer; Laura B Cantwell; Beth A Dombroski; Duane Beekly; Kathryn L Lunetta; Eden R Martin; M Ilyas Kamboh; Andrew J Saykin; Eric M Reiman; David A Bennett; John C Morris; Thomas J Montine; Alison M Goate; Deborah Blacker; Debby W Tsuang; Hakon Hakonarson; Walter A Kukull; Tatiana M Foroud; Jonathan L Haines; Richard Mayeux; Margaret A Pericak-Vance; Lindsay A Farrer; Gerard D Schellenberg
Journal:  Nat Genet       Date:  2011-04-03       Impact factor: 38.330

9.  KEGG for integration and interpretation of large-scale molecular data sets.

Authors:  Minoru Kanehisa; Susumu Goto; Yoko Sato; Miho Furumichi; Mao Tanabe
Journal:  Nucleic Acids Res       Date:  2011-11-10       Impact factor: 16.971

10.  Knowledge-driven analysis identifies a gene-gene interaction affecting high-density lipoprotein cholesterol levels in multi-ethnic populations.

Authors:  Li Ma; Ariel Brautbar; Eric Boerwinkle; Charles F Sing; Andrew G Clark; Alon Keinan
Journal:  PLoS Genet       Date:  2012-05-24       Impact factor: 5.917
View more
  18 in total

Review 1.  Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials.

Authors:  Michael W Weiner; Dallas P Veitch; Paul S Aisen; Laurel A Beckett; Nigel J Cairns; Robert C Green; Danielle Harvey; Clifford R Jack; William Jagust; John C Morris; Ronald C Petersen; Andrew J Saykin; Leslie M Shaw; Arthur W Toga; John Q Trojanowski
Journal:  Alzheimers Dement       Date:  2017-03-22       Impact factor: 21.566

Review 2.  2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception.

Authors:  Michael W Weiner; Dallas P Veitch; Paul S Aisen; Laurel A Beckett; Nigel J Cairns; Jesse Cedarbaum; Robert C Green; Danielle Harvey; Clifford R Jack; William Jagust; Johan Luthman; John C Morris; Ronald C Petersen; Andrew J Saykin; Leslie Shaw; Li Shen; Adam Schwarz; Arthur W Toga; John Q Trojanowski
Journal:  Alzheimers Dement       Date:  2015-06       Impact factor: 21.566

Review 3.  Dantrolene, a treatment for Alzheimer disease?

Authors:  Li Liang; Huafeng Wei
Journal:  Alzheimer Dis Assoc Disord       Date:  2015 Jan-Mar       Impact factor: 2.703

4.  Generalized reduced rank latent factor regression for high dimensional tensor fields, and neuroimaging-genetic applications.

Authors:  Chenyang Tao; Thomas E Nichols; Xue Hua; Christopher R K Ching; Edmund T Rolls; Paul M Thompson; Jianfeng Feng
Journal:  Neuroimage       Date:  2016-09-22       Impact factor: 6.556

5.  Differential rescue of spatial memory deficits in aged rats by L-type voltage-dependent calcium channel and ryanodine receptor antagonism.

Authors:  S C Hopp; H M D'Angelo; S E Royer; R M Kaercher; L Adzovic; G L Wenk
Journal:  Neuroscience       Date:  2014-09-16       Impact factor: 3.590

6.  Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk.

Authors:  Timothy J Hohman; Jessica N Cooke-Bailey; Christiane Reitz; Gyungah Jun; Adam Naj; Gary W Beecham; Zhi Liu; Regina M Carney; Jeffrey M Vance; Michael L Cuccaro; Ruchita Rajbhandary; Badri Narayan Vardarajan; Li-San Wang; Otto Valladares; Chiao-Feng Lin; Eric B Larson; Neill R Graff-Radford; Denis Evans; Philip L De Jager; Paul K Crane; Joseph D Buxbaum; Jill R Murrell; Towfique Raj; Nilufer Ertekin-Taner; Mark W Logue; Clinton T Baldwin; Robert C Green; Lisa L Barnes; Laura B Cantwell; M Daniele Fallin; Rodney C P Go; Patrick Griffith; Thomas O Obisesan; Jennifer J Manly; Kathryn L Lunetta; M Ilyas Kamboh; Oscar L Lopez; David A Bennett; John Hardy; Hugh C Hendrie; Kathleen S Hall; Alison M Goate; Rosalyn Lang; Goldie S Byrd; Walter A Kukull; Tatiana M Foroud; Lindsay A Farrer; Eden R Martin; Margaret A Pericak-Vance; Gerard D Schellenberg; Richard Mayeux; Jonathan L Haines; Tricia A Thornton-Wells
Journal:  Alzheimers Dement       Date:  2015-06-16       Impact factor: 21.566

7.  Genetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort.

Authors:  Jin Li; Qiushi Zhang; Feng Chen; Jingwen Yan; Sungeun Kim; Lei Wang; Weixing Feng; Andrew J Saykin; Hong Liang; Li Shen
Journal:  Biomed Res Int       Date:  2015-09-03       Impact factor: 3.411

8.  Genetic variation modifies risk for neurodegeneration based on biomarker status.

Authors:  Timothy J Hohman; Mary Ellen I Koran; Tricia A Thornton-Wells
Journal:  Front Aging Neurosci       Date:  2014-08-04       Impact factor: 5.750

9.  Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium.

Authors:  Timothy J Hohman; William S Bush; Lan Jiang; Kristin D Brown-Gentry; Eric S Torstenson; Scott M Dudek; Shubhabrata Mukherjee; Adam Naj; Brian W Kunkle; Marylyn D Ritchie; Eden R Martin; Gerard D Schellenberg; Richard Mayeux; Lindsay A Farrer; Margaret A Pericak-Vance; Jonathan L Haines; Tricia A Thornton-Wells
Journal:  Neurobiol Aging       Date:  2015-11-06       Impact factor: 4.673

10.  Hippocampal Subregion and Gene Detection in Alzheimer's Disease Based on Genetic Clustering Random Forest.

Authors:  Jin Li; Wenjie Liu; Luolong Cao; Haoran Luo; Siwen Xu; Peihua Bao; Xianglian Meng; Hong Liang; Shiaofen Fang
Journal:  Genes (Basel)       Date:  2021-05-01       Impact factor: 4.096
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.