Literature DB >> 24026006

A highly selective probe for human cytochrome P450 3A4: isoform selectivity, kinetic characterization and its applications.

Guang-Bo Ge1, Jing Ning, Liang-Hai Hu, Zi-Ru Dai, Jie Hou, Yun-Feng Cao, Zhen-Wen Yu, Chun-Zhi Ai, Jing-Kai Gu, Xiao-Chi Ma, Ling Yang.   

Abstract

Bufalin 5β-hydroxylation was found to be an isoform-specific biotransformation probe substrate for cytochrome P450 3A4 (CYP3A4). The probe reaction was well-characterized and it can be used for measuring the real catalytic activities of CYP3A4 from different enzyme sources.

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Year:  2013        PMID： 24026006     DOI： 10.1039/c3cc45250f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  10 in total

Review 1.  Mechanism-based inactivation of CYP450 enzymes: a case study of lapatinib.

Authors:  Han Kiat Ho; James Chun Yip Chan; Klarissa D Hardy; Eric Chun Yong Chan
Journal:  Drug Metab Rev       Date:  2015-02-02       Impact factor: 4.518

2.  Metabolic Profile of 3-Acetyl-11-Keto-β-Boswellic Acid and 11-Keto-β-Boswellic Acid in Human Preparations In Vitro, Species Differences, and Bioactivity Variation.

Authors:  Yonglei Cui; Xiangge Tian; Jing Ning; Chao Wang; Zhenlong Yu; Yan Wang; Xiaokui Huo; Lingling Jin; Sa Deng; Baojing Zhang; Xiaochi Ma
Journal:  AAPS J       Date:  2016-06-21       Impact factor: 4.009

3.  A novel near-infrared fluorescent probe for sensitive detection of β-galactosidase in living cells.

Authors:  Jingtuo Zhang; Cong Li; Colina Dutta; Mingxi Fang; Shuwei Zhang; Ashutosh Tiwari; Thomas Werner; Fen-Tair Luo; Haiying Liu
Journal:  Anal Chim Acta       Date:  2017-03-08       Impact factor: 6.558

4.  Gomisin A is a Novel Isoform-Specific Probe for the Selective Sensing of Human Cytochrome P450 3A4 in Liver Microsomes and Living Cells.

Authors:  Jing-Jing Wu; Guang-Bo Ge; Yu-Qi He; Ping Wang; Zi-Ru Dai; Jing Ning; Liang-Hai Hu; Ling Yang
Journal:  AAPS J       Date:  2015-09-11       Impact factor: 4.009

5.  Regioselective glucuronidation of andrographolide and its major derivatives: metabolite identification, isozyme contribution, and species differences.

Authors:  Xiangge Tian; Sicheng Liang; Chao Wang; Baojian Wu; Guangbo Ge; Sa Deng; Kexin Liu; Ling Yang; Xiaochi Ma
Journal:  AAPS J       Date:  2014-09-10       Impact factor: 4.009

6.  Identifying and applying a highly selective probe to simultaneously determine the O-glucuronidation activity of human UGT1A3 and UGT1A4.

Authors:  Li Jiang; Si-Cheng Liang; Chao Wang; Guang-Bo Ge; Xiao-Kui Huo; Xiao-Yi Qi; Sa Deng; Ke-Xin Liu; Xiao-Chi Ma
Journal:  Sci Rep       Date:  2015-04-17       Impact factor: 4.379

7.  A Mechanism-Based Model for the Prediction of the Metabolic Sites of Steroids Mediated by Cytochrome P450 3A4.

Authors:  Zi-Ru Dai; Chun-Zhi Ai; Guang-Bo Ge; Yu-Qi He; Jing-Jing Wu; Jia-Yue Wang; Hui-Zi Man; Yan Jia; Ling Yang
Journal:  Int J Mol Sci       Date:  2015-06-30       Impact factor: 5.923

8.  A practical strategy to design and develop an isoform-specific fluorescent probe for a target enzyme: CYP1A1 as a case study.

Authors:  Zi-Ru Dai; Lei Feng; Qiang Jin; Hailing Cheng; Yan Li; Jing Ning; Yang Yu; Guang-Bo Ge; Jing-Nan Cui; Ling Yang
Journal:  Chem Sci       Date:  2016-12-19       Impact factor: 9.825

9.  Pyroglutamate aminopeptidase 1 may be an indicator of cellular inflammatory response as revealed using a sensitive long-wavelength fluorescent probe.

Authors:  Qiuyu Gong; Lihong Li; Xiaofeng Wu; Huimin Ma
Journal:  Chem Sci       Date:  2016-04-11       Impact factor: 9.825

10.  A highly specific ratiometric two-photon fluorescent probe to detect dipeptidyl peptidase IV in plasma and living systems.

Authors:  Li-Wei Zou; Ping Wang; Xing-Kai Qian; Lei Feng; Yang Yu; Dan-Dan Wang; Qiang Jin; Jie Hou; Zhi-Hong Liu; Guang-Bo Ge; Ling Yang
Journal:  Biosens Bioelectron       Date:  2016-11-30       Impact factor: 10.618
  10 in total

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