AIM: To identify loci associated with chronic periodontitis through a genome-wide association study (GWAS). MATERIALS AND METHODS: A GWAS was performed in 4032 individuals of two independent cross-sectional studies of West Pomerania (SHIP n = 3365 and SHIP-TREND n = 667) with different periodontal case definitions. Samples were genotyped with the Affymetrix Genome-Wide Human SNP Array 6.0 or the Illumina Human Omni 2.5 array. Imputation of the HapMap as well as the 1000 Genome-based autosomal and X-chromosomal genotypes and short insertions and deletions (INDELs) was performed in both cohorts. Finally, more than 17 million SNPs and short INDELs were analysed. RESULTS: No genome-wide significant associations were found for any periodontitis case definition, regardless of whether individuals aged >60 years where excluded or not. Despite no single SNP association reached genome-wide significance, the proportion of variance explained by additive effects of all common SNPs was around 23% for mean proximal attachment loss. Excluding subjects aged >60 years increased the explained variance to 34%. CONCLUSIONS: No single SNPs were found to be genome-wide significantly associated with chronic periodontitis in this study.
AIM: To identify loci associated with chronic periodontitis through a genome-wide association study (GWAS). MATERIALS AND METHODS: A GWAS was performed in 4032 individuals of two independent cross-sectional studies of West Pomerania (SHIP n = 3365 and SHIP-TREND n = 667) with different periodontal case definitions. Samples were genotyped with the Affymetrix Genome-Wide Human SNP Array 6.0 or the Illumina Human Omni 2.5 array. Imputation of the HapMap as well as the 1000 Genome-based autosomal and X-chromosomal genotypes and short insertions and deletions (INDELs) was performed in both cohorts. Finally, more than 17 million SNPs and short INDELs were analysed. RESULTS: No genome-wide significant associations were found for any periodontitis case definition, regardless of whether individuals aged >60 years where excluded or not. Despite no single SNP association reached genome-wide significance, the proportion of variance explained by additive effects of all common SNPs was around 23% for mean proximal attachment loss. Excluding subjects aged >60 years increased the explained variance to 34%. CONCLUSIONS: No single SNPs were found to be genome-wide significantly associated with chronic periodontitis in this study.
Authors: Matthias Munz; Gesa M Richter; Bruno G Loos; Søren Jepsen; Kimon Divaris; Steven Offenbacher; Alexander Teumer; Birte Holtfreter; Thomas Kocher; Corinna Bruckmann; Yvonne Jockel-Schneider; Christian Graetz; Ilyas Ahmad; Ingmar Staufenbiel; Nathalie van der Velde; André G Uitterlinden; Lisette C P G M de Groot; Jürgen Wellmann; Klaus Berger; Bastian Krone; Per Hoffmann; Matthias Laudes; Wolfgang Lieb; Andre Franke; Jeanette Erdmann; Henrik Dommisch; Arne S Schaefer Journal: Eur J Hum Genet Date: 2018-09-14 Impact factor: 4.246
Authors: A A Akinkugbe; C L Avery; A S Barritt; S R Cole; M Lerch; J Mayerle; S Offenbacher; A Petersmann; M Nauck; H Völzke; G D Slade; G Heiss; T Kocher; B Holtfreter Journal: J Dent Res Date: 2017-07-21 Impact factor: 6.116
Authors: K A Elisa Kallio; Marja Marchesani; Efthymia Vlachopoulou; Päivi Mäntylä; Susanna Paju; Kåre Buhlin; Anna L Suominen; Johanna Contreras; Matti Knuuttila; Marcela Hernandez; Sisko Huumonen; Markku S Nieminen; Markus Perola; Juha Sinisalo; Marja-Liisa Lokki; Pirkko J Pussinen Journal: Infect Immun Date: 2014-02-24 Impact factor: 3.441
Authors: Cary S Agler; Dmitry Shungin; Andrea G Ferreira Zandoná; Paige Schmadeke; Patricia V Basta; Jason Luo; John Cantrell; Thomas D Pahel; Beau D Meyer; John R Shaffer; Arne S Schaefer; Kari E North; Kimon Divaris Journal: Methods Mol Biol Date: 2019