Literature DB >> 24024867

Towards a better cannabis drug.

Raphael Mechoulam1, Linda Parker.   

Abstract

UNLABELLED: This commentary discusses the importance of a new study entitled 'Cannabidiol attenuates deficits of visuo-spatial associative memory induced by Δ(9) -tetrahydrocannabinol' by Wright et al. from the Scripps Institute in La Jolla, California. The results in this study show that the non-psychoactive cannabis constituent cannabidiol opposes some, but not all, forms of behavioural and memory disruption caused by Δ(9) -tetrahydrocannabinol in male rhesus monkeys. LINKED ARTICLE: This article is a commentary on the research paper by Wright et al., pp 1365-1373 of this issue. To view this paper visit http://dx.doi.org/10.1111/bph.12199.
© 2013 The British Pharmacological Society.

Entities:  

Keywords:  CBD; THC; cannabidiol; cannabis; cognition; learning; memory; motivation; sensorimotor; Δ9-tetrahydrocannabinol

Mesh：

Substances：

Year:  2013        PMID： 24024867      PMCID： PMC3838682          DOI： 10.1111/bph.12400

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  12 in total

1.  A randomized, double-blind, placebo-controlled, crossover study to evaluate the subjective abuse potential and cognitive effects of nabiximols oromucosal spray in subjects with a history of recreational cannabis use.

Authors:  Kerri Alexandra Schoedel; Nancy Chen; Annie Hilliard; Linda White; Colin Stott; Ethan Russo; Stephen Wright; Geoffrey Guy; Myroslava K Romach; Edward M Sellers
Journal:  Hum Psychopharmacol       Date:  2011-04       Impact factor: 1.672

Review 2.  The endocannabinoid system and the brain.

Authors:  Raphael Mechoulam; Linda A Parker
Journal:  Annu Rev Psychol       Date:  2012-07-12       Impact factor: 24.137

Review 3.  Is lipid signaling through cannabinoid 2 receptors part of a protective system?

Authors:  P Pacher; R Mechoulam
Journal:  Prog Lipid Res       Date:  2011-02-02       Impact factor: 16.195

4.  Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study: naturalistic study [corrected].

Authors:  Celia J A Morgan; Gráinne Schafer; Tom P Freeman; H Valerie Curran
Journal:  Br J Psychiatry       Date:  2010-10       Impact factor: 9.319

Review 5.  Abuse potential and psychoactive effects of δ-9-tetrahydrocannabinol and cannabidiol oromucosal spray (Sativex), a new cannabinoid medicine.

Authors:  Philip Robson
Journal:  Expert Opin Drug Saf       Date:  2011-05-04       Impact factor: 4.250

6.  Δ⁹Tetrahydrocannabinol impairs visuo-spatial associative learning and spatial working memory in rhesus macaques.

Authors:  Michael A Taffe
Journal:  J Psychopharmacol       Date:  2012-04-22       Impact factor: 4.153

7.  Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients.

Authors:  Derick T Wade; Petra Makela; Philip Robson; Heather House; Cynthia Bateman
Journal:  Mult Scler       Date:  2004-08       Impact factor: 6.312

8.  The effects of delta 9-tetrahydrocannabinol alone and in combination with cannabidiol on fixed-interval performance in rhesus monkeys.

Authors:  K T Brady; R L Balster
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530

9.  Beta-caryophyllene is a dietary cannabinoid.

Authors:  Jürg Gertsch; Marco Leonti; Stefan Raduner; Ildiko Racz; Jian-Zhong Chen; Xiang-Qun Xie; Karl-Heinz Altmann; Meliha Karsak; Andreas Zimmer
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-23       Impact factor: 11.205

10.  Cannabidiol attenuates deficits of visuospatial associative memory induced by Δ(9) tetrahydrocannabinol.

Authors:  M Jerry Wright; Sophia A Vandewater; Michael A Taffe
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739
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  9 in total

1.  Palmitoyl Serine: An Endogenous Neuroprotective Endocannabinoid-Like Entity After Traumatic Brain Injury.

Authors:  Aniv Mann; Reem Smoum; Victoria Trembovler; Alexander Alexandrovich; Aviva Breuer; Raphael Mechoulam; Esther Shohami
Journal:  J Neuroimmune Pharmacol       Date:  2015-02-27       Impact factor: 4.147

Review 2.  Seeing through the smoke: Human and animal studies of cannabis use and endocannabinoid signalling in corticolimbic networks.

Authors:  Mason M Silveira; Jonathon C Arnold; Steven R Laviolette; Cecilia J Hillard; Marta Celorrio; María S Aymerich; Wendy K Adams
Journal:  Neurosci Biobehav Rev       Date:  2016-09-14       Impact factor: 8.989

Review 3.  The Medicinal Cannabis Treatment Agreement: Providing Information to Chronic Pain Patients Through a Written Document.

Authors:  Barth Wilsey; J Hampton Atkinson; Thomas D Marcotte; Igor Grant
Journal:  Clin J Pain       Date:  2015-12       Impact factor: 3.442

Review 4.  The endocannabinoid system as a target for novel anxiolytic drugs.

Authors:  Sachin Patel; Mathew N Hill; Joseph F Cheer; Carsten T Wotjak; Andrew Holmes
Journal:  Neurosci Biobehav Rev       Date:  2017-05       Impact factor: 8.989

5.  A Novel Observational Method for Assessing Acute Responses to Cannabis: Preliminary Validation Using Legal Market Strains.

Authors:  L Cinnamon Bidwell; Raeghan Mueller; Sophie L YorkWilliams; Sarah Hagerty; Angela D Bryan; Kent E Hutchison
Journal:  Cannabis Cannabinoid Res       Date:  2018-03-01

6.  Oral Cannabidiol does not Alter the Subjective, Reinforcing or Cardiovascular Effects of Smoked Cannabis.

Authors:  Margaret Haney; Robert J Malcolm; Shanna Babalonis; Paul A Nuzzo; Ziva D Cooper; Gillinder Bedi; Kevin M Gray; Aimee McRae-Clark; Michelle R Lofwall; Steven Sparenborg; Sharon L Walsh
Journal:  Neuropsychopharmacology       Date:  2015-12-28       Impact factor: 7.853

7.  An Exploratory Human Laboratory Experiment Evaluating Vaporized Cannabis in the Treatment of Neuropathic Pain From Spinal Cord Injury and Disease.

Authors:  Barth Wilsey; Thomas D Marcotte; Reena Deutsch; Holly Zhao; Hannah Prasad; Amy Phan
Journal:  J Pain       Date:  2016-06-07       Impact factor: 5.820

8.  The Efficacy of Cannabis in Reducing Back Pain: A Systematic Review.

Authors:  Richard L Price; Kaarina V Charlot; Sven Frieler; Joseph R Dettori; Rod Oskouian; Jens R Chapman
Journal:  Global Spine J       Date:  2022-02-07

9.  Evidence for side effects of cannabidiol (CBD) products and their non-conformity on the European food market - response to the European Industrial Hemp Association.

Authors:  Dirk W Lachenmeier; Stephan G Walch
Journal:  F1000Res       Date:  2020-08-26
  9 in total

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