Junbao Liu1, Yanqing Liu. 1. The First Clinical College of Nanjing University of Chinese Medicine, Nanjing 210029, China.
Abstract
OBJECTIVE: To investigate the effects and mechanisms of Erbanxiao solution in inhibiting tumor angiogenesis. METHODS: We observed the effects and mechanisms of Chinese medicines on inhibiting tumor angiogenesis and studied the theories and results of treatment. Sixty patients with lung cancer were randomized into two groups (n = 30). Patients in the control group were given compound Kushen injection, and patients in the treatment group were given Erbanxiao solution. The effect of Erbanxiao solution on vascular endothelium growth factor (VEGF), basic fibroblast growth factor (bFGF), and tumor necrosis factor-alpha (TNF-alpha) was observed. RESULTS: The effective rate of the treatment group was 60% while the control group was 36%. There was a significant difference between the two groups (P < 0.05). VEGF, bFGF, and TNF-alpha levels of the two groups were significantly different before and after treatment (P < 0.01). These Traditional Chinese Medicines significantly inhibited tumor angiogenesis, possibly by changing levels of VEGF, bFGF, and TNF-alpha. CONCLUSION: It is necessary to further explore the potential of Traditional Chinese Medicine in the treatment of angiogenesis in tumor patients.
RCT Entities:
OBJECTIVE: To investigate the effects and mechanisms of Erbanxiao solution in inhibiting tumor angiogenesis. METHODS: We observed the effects and mechanisms of Chinese medicines on inhibiting tumor angiogenesis and studied the theories and results of treatment. Sixty patients with lung cancer were randomized into two groups (n = 30). Patients in the control group were given compound Kushen injection, and patients in the treatment group were given Erbanxiao solution. The effect of Erbanxiao solution on vascular endothelium growth factor (VEGF), basic fibroblast growth factor (bFGF), and tumor necrosis factor-alpha (TNF-alpha) was observed. RESULTS: The effective rate of the treatment group was 60% while the control group was 36%. There was a significant difference between the two groups (P < 0.05). VEGF, bFGF, and TNF-alpha levels of the two groups were significantly different before and after treatment (P < 0.01). These Traditional Chinese Medicines significantly inhibited tumor angiogenesis, possibly by changing levels of VEGF, bFGF, and TNF-alpha. CONCLUSION: It is necessary to further explore the potential of Traditional Chinese Medicine in the treatment of angiogenesis in tumorpatients.