Literature DB >> 24024115

Obesity and the gut microbiome: Striving for causality.

Isaac T W Harley1, Christopher L Karp.   

Abstract

The gut microbiome has been proposed to play a causal role in obesity. Here, we review the historical context for this hypothesis, highlight recent key findings, and critically discuss issues central to further progress in the field, including the central epistemological problem for the field: how to define causality in the relationship between microbiota and obesity phenotypes. Definition of such will be critical for the field to move forward.

Entities:  

Keywords:  Innate immunity; Microbiome; Microbiota; Non-alcoholic fatty liver disease; Obesity; Segmented filamentous bacteria; Type 2 diabetes

Year:  2012        PMID： 24024115      PMCID： PMC3757651          DOI： 10.1016/j.molmet.2012.07.002

Source DB:  PubMed          Journal:  Mol Metab        ISSN： 2212-8778            Impact factor:   7.422


  137 in total

1.  Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors.

Authors:  Andrew K Benson; Scott A Kelly; Ryan Legge; Fangrui Ma; Soo Jen Low; Jaehyoung Kim; Min Zhang; Phaik Lyn Oh; Derrick Nehrenberg; Kunjie Hua; Stephen D Kachman; Etsuko N Moriyama; Jens Walter; Daniel A Peterson; Daniel Pomp
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-11       Impact factor: 11.205

2.  T-ing up inflammation in fat.

Authors:  Carey N Lumeng; Ivan Maillard; Alan R Saltiel
Journal:  Nat Med       Date:  2009-08       Impact factor: 53.440

3.  Mechanisms underlying the resistance to diet-induced obesity in germ-free mice.

Authors:  Fredrik Bäckhed; Jill K Manchester; Clay F Semenkovich; Jeffrey I Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-08       Impact factor: 11.205

Review 4.  The metabolic syndrome.

Authors:  Robert H Eckel; Scott M Grundy; Paul Z Zimmet
Journal:  Lancet       Date:  2005 Apr 16-22       Impact factor: 79.321

5.  A humanized gnotobiotic mouse model of host-archaeal-bacterial mutualism.

Authors:  Buck S Samuel; Jeffrey I Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  2006-06-16       Impact factor: 11.205

6.  Inflammasome is a central player in the induction of obesity and insulin resistance.

Authors:  Rinke Stienstra; Janna A van Diepen; Cees J Tack; Md Hasan Zaki; Frank L van de Veerdonk; Deshani Perera; Geoffrey A Neale; Guido J Hooiveld; Anneke Hijmans; Irene Vroegrijk; Sjoerd van den Berg; Johannes Romijn; Patrick C N Rensen; Leo A B Joosten; Mihai G Netea; Thirumala-Devi Kanneganti
Journal:  Proc Natl Acad Sci U S A       Date:  2011-08-29       Impact factor: 11.205

7.  Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.

Authors:  Eugenia E Calle; Carmen Rodriguez; Kimberly Walker-Thurmond; Michael J Thun
Journal:  N Engl J Med       Date:  2003-04-24       Impact factor: 91.245

8.  Evidence that opioids may have toll-like receptor 4 and MD-2 effects.

Authors:  Mark R Hutchinson; Yingning Zhang; Mitesh Shridhar; John H Evans; Madison M Buchanan; Tina X Zhao; Peter F Slivka; Benjamen D Coats; Niloofar Rezvani; Julie Wieseler; Travis S Hughes; Kyle E Landgraf; Stefanie Chan; Stephanie Fong; Simon Phipps; Joseph J Falke; Leslie A Leinwand; Steven F Maier; Hang Yin; Kenner C Rice; Linda R Watkins
Journal:  Brain Behav Immun       Date:  2009-08-11       Impact factor: 7.217

9.  Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.

Authors:  G S Hotamisligil; N S Shargill; B M Spiegelman
Journal:  Science       Date:  1993-01-01       Impact factor: 47.728

10.  Linking long-term dietary patterns with gut microbial enterotypes.

Authors:  Gary D Wu; Jun Chen; Christian Hoffmann; Kyle Bittinger; Ying-Yu Chen; Sue A Keilbaugh; Meenakshi Bewtra; Dan Knights; William A Walters; Rob Knight; Rohini Sinha; Erin Gilroy; Kernika Gupta; Robert Baldassano; Lisa Nessel; Hongzhe Li; Frederic D Bushman; James D Lewis
Journal:  Science       Date:  2011-09-01       Impact factor: 47.728
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  36 in total

1.  Differential colonization with segmented filamentous bacteria and Lactobacillus murinus do not drive divergent development of diet-induced obesity in C57BL/6 mice.

Authors:  Isaac T W Harley; Daniel A Giles; Paul T Pfluger; Stacey L Burgess; Stephanie Walters; Jazzminn Hembree; Christine Raver; Cheryl L Rewerts; Jordan Downey; Leah M Flick; Traci E Stankiewicz; Jaclyn W McAlees; Marsha Wills-Karp; R Balfour Sartor; Senad Divanovic; Matthias H Tschöp; Christopher L Karp
Journal:  Mol Metab       Date:  2013-05-10       Impact factor: 7.422

Review 2.  Probiotics and pregnancy.

Authors:  Luisa F Gomez Arango; Helen L Barrett; Leonie K Callaway; Marloes Dekker Nitert
Journal:  Curr Diab Rep       Date:  2015-01       Impact factor: 4.810

Review 3.  Gut microbiota impact on stroke outcome: Fad or fact?

Authors:  Katarzyna Winek; Andreas Meisel; Ulrich Dirnagl
Journal:  J Cereb Blood Flow Metab       Date:  2016-03-04       Impact factor: 6.200

Review 4.  Links between Immunologic Memory and Metabolic Cycling.

Authors:  Matthew A Cottam; Hana A Itani; Arch A Beasley; Alyssa H Hasty
Journal:  J Immunol       Date:  2018-06-01       Impact factor: 5.422

5.  Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet-Induced Obese Mice.

Authors:  Isabelle E Logan; Natalia Shulzhenko; Thomas J Sharpton; Gerd Bobe; Kitty Liu; Stephanie Nuss; Megan L Jones; Cristobal L Miranda; Stephany Vasquez-Perez; Jamie M Pennington; Scott W Leonard; Jaewoo Choi; Wenbin Wu; Manoj Gurung; Joyce P Kim; Malcolm B Lowry; Andrey Morgun; Claudia S Maier; Jan F Stevens; Adrian F Gombart
Journal:  Mol Nutr Food Res       Date:  2021-10-12       Impact factor: 5.914

6.  Phage Cocktail Targeting STEC O157:H7 Has Comparable Efficacy and Superior Recovery Compared with Enrofloxacin in an Enteric Murine Model.

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7.  Systemic lupus erythematosus as a genetic disease.

Authors:  Isaac T W Harley; Amr H Sawalha
Journal:  Clin Immunol       Date:  2022-02-09       Impact factor: 10.190

8.  Synergistic effect of Lactobacillus gasseri and Cudrania tricuspidata on the modulation of body weight and gut microbiota structure in diet-induced obese mice.

Authors:  Ju Kyoung Oh; Mia Beatriz C Amoranto; Nam Su Oh; Sejeong Kim; Ji Young Lee; Ye Na Oh; Yong Kook Shin; Yohan Yoon; Dae-Kyung Kang
Journal:  Appl Microbiol Biotechnol       Date:  2020-05-11       Impact factor: 4.813

9.  Associations of the Oral Microbiota with Obesity and Menarche in Inner City Girls.

Authors:  Nancy A Mervish; Jianzhong Hu; Loy A Hagan; Manish Arora; Catalina Frau; Julee Choi; Ali Attaie; Mairaj Ahmed; Susan L Teitelbaum; Mary S Wolff
Journal:  J Child Obes       Date:  2019-03-13

10.  Targeted Approaches for In Situ Gut Microbiome Manipulation.

Authors:  Gail A M Cresci; Johanna W Lampe; Glenn Gibson
Journal:  JPEN J Parenter Enteral Nutr       Date:  2020-02-06       Impact factor: 3.896
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