Literature DB >> 24023416

Comparative insights using the molecular homology model of BDNF (Brain derived neurotrophic factor) of Varanus komodoensis and the known NGF (Nerve growth factor) structure of Naja atra.

Ankit Verma1, Dhirendra Kumar Sharma, Rituparna Sarma, Hasnahana Chetia, Juri Saikia.   

Abstract

BDNF (Brain derived neurotrophic factor) is a secretion protein and a member of the neurotrophin family of growth factors. Structural and functional characterization of BDNF Varanus komodoensis is of interest while its structure remains unknown. Thus, a homology molecular model of BDNF was constructed for gleaning possible structural insights. The model was compared with the structure of the homologous NGF (Nerve growth factor, another member of neuro-trophin family) from Naja atra. Comparative structural analysis of the models showed structural similarities with their predicted cavities for the interpretation of potential functional analogy.

Entities:  

Year:  2013        PMID： 24023416      PMCID： PMC3766306          DOI： 10.6026/97320630009755

Source DB:  PubMed          Journal:  Bioinformation        ISSN： 0973-2063


  25 in total

1.  The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site.

Authors:  R C Robinson; C Radziejewski; G Spraggon; J Greenwald; M R Kostura; L D Burtnick; D I Stuart; S Choe; E Y Jones
Journal:  Protein Sci       Date:  1999-12       Impact factor: 6.725

2.  Interactions between brain-derived neurotrophic factor and the TRKB receptor. Identification of two ligand binding domains in soluble TRKB by affinity separation and chemical cross-linking.

Authors:  M Haniu; S Montestruque; E J Bures; J Talvenheimo; R Toso; S Lewis-Sandy; A A Welcher; M F Rohde
Journal:  J Biol Chem       Date:  1997-10-03       Impact factor: 5.157

3.  Anatomy of protein pockets and cavities: measurement of binding site geometry and implications for ligand design.

Authors:  J Liang; H Edelsbrunner; C Woodward
Journal:  Protein Sci       Date:  1998-09       Impact factor: 6.725

4.  Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice.

Authors:  M Ono; J Ichihara; T Nonomura; Y Itakura; M Taiji; C Nakayama; H Noguchi
Journal:  Biochem Biophys Res Commun       Date:  1997-09-18       Impact factor: 3.575

5.  Cognitive and serotonergic vulnerability to depression: convergent findings.

Authors:  Linda Booij; A J Willem Van der Does
Journal:  J Abnorm Psychol       Date:  2007-02

6.  Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice.

Authors:  T Nakagawa; A Tsuchida; Y Itakura; T Nonomura; M Ono; F Hirota; T Inoue; C Nakayama; M Taiji; H Noguchi
Journal:  Diabetes       Date:  2000-03       Impact factor: 9.461

7.  Modulation of dendritic spine development and plasticity by BDNF and vesicular trafficking: fundamental roles in neurodevelopmental disorders associated with mental retardation and autism.

Authors:  Christopher A Chapleau; Jennifer L Larimore; Anne Theibert; Lucas Pozzo-Miller
Journal:  J Neurodev Disord       Date:  2009-09       Impact factor: 4.025

8.  The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function.

Authors:  Michael F Egan; Masami Kojima; Joseph H Callicott; Terry E Goldberg; Bhaskar S Kolachana; Alessandro Bertolino; Eugene Zaitsev; Bert Gold; David Goldman; Michael Dean; Bai Lu; Daniel R Weinberger
Journal:  Cell       Date:  2003-01-24       Impact factor: 41.582

9.  Cellular localization of brain-derived neurotrophic factor and neurotrophin-3 mRNA expression in the early chicken embryo.

Authors:  F Hallböök; C F Ibáñez; T Ebendal; H Persson
Journal:  Eur J Neurosci       Date:  1993-01-01       Impact factor: 3.386

10.  Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor.

Authors:  A Rodríguez-Tébar; G Dechant; R Götz; Y A Barde
Journal:  EMBO J       Date:  1992-03       Impact factor: 11.598
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  1 in total

1.  The Effects of Hesperidin on BDNF/TrkB Signaling Pathway and Oxidative Stress Parameters in the Cerebral Cortex of the Utero-placental Insufficiency Fetal Rat Model.

Authors:  Hamed Abdollahi; Mohammad Amin Edalatmanesh; Ebrahim Hosseini; Mohsen Foroozanfar
Journal:  Basic Clin Neurosci       Date:  2021-07-01
  1 in total

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