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Literature DB >> 240234

Induction of neurogenic tumors by nitrosotrialkylureas in rats.

Abstract

Four nitrosotrialkylureas were each fed to groups of 15 male and 15 female Sprague-Dawley rats for 50 weeks in drinking water at the same molar concentration. Tumors of nervous origin arose after treatment with nitrosotrimethylurea (3/30), notrosotriethylurea (7/30), nitrosomethyldiethylurea (23/30), and nitrosoethyldimethylurea (8/30). A comparison of the relative stabilities of the four nitrosoureas in aqueous solution at various pH's showed no correlation with the tumorigenicities of the compounds.

Entities: Chemical Disease Species

Mesh：

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Year: 1975 PMID： 240234 DOI： 10.1007/bf00573018

Source DB: PubMed Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol ISSN： 0084-5353

7 in total

1. [Induction of neurogenic malignancies by one single dose of ethyl-nitrosourea (ENU) given to newborn and juvenile BD IX-strain rats].

Authors: H Druckrey; B Schagen; S Ivankovic
Journal: Z Krebsforsch Date: 1970

2. [Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats].

Authors: H Druckrey; R Preussmann; S Ivankovic; D Schmähl
Journal: Z Krebsforsch Date: 1967

3. Alkylation of rat brain nucleic acids by N-methyl-N-nitrosourea and methyl methanesulphonate.

Authors: P Kleihues; P N Magee
Journal: J Neurochem Date: 1973-02 Impact factor: 5.372

4. Carcinogenesis and alkylation of rat liver nucleic acids by nitrosomethylurea and nitrosoethylurea administered by intraportal injection.

Authors: W Lijinsky; H Garcia; L Keefer; J Loo; A E Ross
Journal: Cancer Res Date: 1972-05 Impact factor: 12.701

5. Ethylation of nucleic acids by ethylnitrosourea-1- 14 C in the fetal and adult rat.

Authors: R Goth; M F Rajewsky
Journal: Cancer Res Date: 1972-07 Impact factor: 12.701

6. The formation of carcinogenic nitroso compounds from nitrite and some types of agricultural chemicals.

Authors: R K Elespuru; W Lijinsky
Journal: Food Cosmet Toxicol Date: 1973-10

7. Nitrosamine-induced carcinogenesis. The alkylation of N-7 of guanine of nucleic acids of the rat by diethylnitrosamine, N-ethyl-N-nitrosourea and ethyl methanesulphonate.

Authors: P F Swann; P N Magee
Journal: Biochem J Date: 1971-12 Impact factor: 3.857

7 in total

4 in total

Induction of neurogenic tumors by nitrosotrialkylureas in rats.

1. [Induction of neurogenic malignancies by one single dose of ethyl-nitrosourea (ENU) given to newborn and juvenile BD IX-strain rats].

2. [Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats].

3. Alkylation of rat brain nucleic acids by N-methyl-N-nitrosourea and methyl methanesulphonate.

4. Carcinogenesis and alkylation of rat liver nucleic acids by nitrosomethylurea and nitrosoethylurea administered by intraportal injection.

5. Ethylation of nucleic acids by ethylnitrosourea-1- 14 C in the fetal and adult rat.

6. The formation of carcinogenic nitroso compounds from nitrite and some types of agricultural chemicals.

7. Nitrosamine-induced carcinogenesis. The alkylation of N-7 of guanine of nucleic acids of the rat by diethylnitrosamine, N-ethyl-N-nitrosourea and ethyl methanesulphonate.

Review 1. Structure-activity relations in carcinogenesis by N-nitroso compounds.

Review 2. Deuterium isotope effects in carcinogenesis by N-nitroso compounds.

3. Species differences in nitrosamine carcinogenesis.

4. Carcinogenicity of chlorinated nitrosotrialkylureas in rats.