BACKGROUND: Protein tyrosine kinase-7 (PTK7) plays an important role in cancer. Our aim was to evaluate PTK7 in triple-negative breast cancer (TNBC). MATERIALS AND METHODS: PTK7 Expression was assessed by immunohistochemistry (IHC) in 133 patients with TNBC. Expression levels were correlated with clinicopathological features and survival, taking chemotherapy into account. RESULTS: Positive PTK7 expression was detected in 28.6% of tumors. In the total population, no significant difference was detected in disease-free survival (DFS) or overall survival (OS) related to PTK7 status. However, in patients treated by chemotherapy, patients with PTK7-negative tumors seemed to have better DFS than those with PTK7-positive tumors, particularly for patients treated with only anthracycline-therapy drugs. In patients receiving other chemotherapy regimens, PTK7 status had no significant impact on DFS or OS. CONCLUSION: Our results support earlier findings that PTK7 may be associated with resistance to anthracycline-based chemotherapy.
BACKGROUND:Protein tyrosine kinase-7 (PTK7) plays an important role in cancer. Our aim was to evaluate PTK7 in triple-negative breast cancer (TNBC). MATERIALS AND METHODS:PTK7 Expression was assessed by immunohistochemistry (IHC) in 133 patients with TNBC. Expression levels were correlated with clinicopathological features and survival, taking chemotherapy into account. RESULTS: Positive PTK7 expression was detected in 28.6% of tumors. In the total population, no significant difference was detected in disease-free survival (DFS) or overall survival (OS) related to PTK7 status. However, in patients treated by chemotherapy, patients with PTK7-negative tumors seemed to have better DFS than those with PTK7-positive tumors, particularly for patients treated with only anthracycline-therapy drugs. In patients receiving other chemotherapy regimens, PTK7 status had no significant impact on DFS or OS. CONCLUSION: Our results support earlier findings that PTK7 may be associated with resistance to anthracycline-based chemotherapy.
Entities:
Keywords:
PTK7; anthracycline resistance; prognosis; triple-negative breast cancer
Authors: Beyhan Ataseven; Angela Gunesch; Wolfgang Eiermann; Ronald E Kates; Bernhard Högel; Pjotr Knyazev; Axel Ullrich; Nadia Harbeck Journal: Onco Targets Ther Date: 2014-10-06 Impact factor: 4.147