BACKGROUND: The N-acetyltransferase 2 (NAT2) gene is a marker for the study of interindividual susceptibility to developing neoplasias. The purpose of this study was to verify a possible association between single nucleotide polymomorphisms (SNPs) of NAT2 and the susceptibility to gastric cancer (GC) and breast cancer (BC) in patients from the North region of Brazil. MATERIALS AND METHODS: Five SNPs of the NAT2 gene were investigated by direct sequencing. Ancestry was estimated by analysis of a panel with 48 ancestry-informative markers (AIM). RESULTS: Individuals with slow acetylation profile had an increased risk of developing neoplasias up to three times when compared to controls. CONCLUSION: In this study, slow acetylation profile was found to strongly influence susceptibility to GC and BC.
BACKGROUND: The N-acetyltransferase 2 (NAT2) gene is a marker for the study of interindividual susceptibility to developing neoplasias. The purpose of this study was to verify a possible association between single nucleotide polymomorphisms (SNPs) of NAT2 and the susceptibility to gastric cancer (GC) and breast cancer (BC) in patients from the North region of Brazil. MATERIALS AND METHODS: Five SNPs of the NAT2 gene were investigated by direct sequencing. Ancestry was estimated by analysis of a panel with 48 ancestry-informative markers (AIM). RESULTS: Individuals with slow acetylation profile had an increased risk of developing neoplasias up to three times when compared to controls. CONCLUSION: In this study, slow acetylation profile was found to strongly influence susceptibility to GC and BC.
Entities:
Keywords:
IAM; NAT2; SNP; breast cancer; cancer susceptibility; gastric cancer
Authors: Amanda Nazaré Cohen Lima de Castro; Marianne Rodrigues Fernandes; Darlen Cardoso de Carvalho; Tatiane Piedade de Souza; Juliana Carla Gomes Rodrigues; Roberta Borges Andrade; Antonio Andre Conde Modesto; Sidney Santos; Paulo Pimentel Assumpção; Ney Pereira Carneiro Dos Santos Journal: Am J Transl Res Date: 2020-10-15 Impact factor: 4.060
Authors: Ellen M McDonagh; Sotiria Boukouvala; Eleni Aklillu; David W Hein; Russ B Altman; Teri E Klein Journal: Pharmacogenet Genomics Date: 2014-08 Impact factor: 2.089
Authors: Petra Kasajova; Veronika Holubekova; Andrea Mendelova; Zora Lasabova; Pavol Zubor; Erik Kudela; Kristina Biskupska-Bodova; Jan Danko Journal: Tumour Biol Date: 2015-12-23