Literature DB >> 24022511

The STIL protein contains intrinsically disordered regions that mediate its protein-protein interactions.

Hadar Amartely1, Ahuvit David, Mario Lebendiker, Hadar Benyamini, Shai Izraeli, Assaf Friedler.   

Abstract

The STIL protein participates in mitosis and malignant transformation by regulating centrosomal duplication. Using biophysical methods we studied the structure and interactions of STIL. We revealed that its central domain is intrinsically disordered and mediates protein-protein interactions of STIL. The intrinsic disorder may provide STIL with the conformational flexibility required for its multitude binding.

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Year:  2013        PMID： 24022511     DOI： 10.1039/c3cc45096a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

1.  Identifying protein-protein interaction sites using peptide arrays.

Authors:  Hadar Amartely; Anat Iosub-Amir; Assaf Friedler
Journal:  J Vis Exp       Date:  2014-11-18       Impact factor: 1.355

2.  Quarterly intrinsic disorder digest (April-May-June, 2014).

Authors:  Shelly DeForte; Vladimir N Uversky
Journal:  Intrinsically Disord Proteins       Date:  2017-03-01

3.  Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer.

Authors:  Noa Rabinowicz; Lingegowda S Mangala; Kevin R Brown; Cintia Checa-Rodriguez; Asher Castiel; Oren Moskovich; Giulia Zarfati; Luba Trakhtenbrot; Adva Levy-Barda; Dahai Jiang; Cristian Rodriguez-Aguayo; Sunila Pradeep; Yael van Praag; Gabriel Lopez-Berestein; Ahuvit David; Ilya Novikov; Pablo Huertas; Robert Rottapel; Anil K Sood; Shai Izraeli
Journal:  Oncotarget       Date:  2017-04-18

Review 4.  Human Brain Organoids to Decode Mechanisms of Microcephaly.

Authors:  Elke Gabriel; Anand Ramani; Nazlican Altinisik; Jay Gopalakrishnan
Journal:  Front Cell Neurosci       Date:  2020-05-08       Impact factor: 5.505

5.  Differential effects of zinc binding on structured and disordered regions in the multidomain STIL protein.

Authors:  Hadar Amartely; Ahuvit David; Mai Shamir; Mario Lebendiker; Shai Izraeli; Assaf Friedler
Journal:  Chem Sci       Date:  2016-03-04       Impact factor: 9.825

6.  Molecular basis of the STIL coiled coil oligomerization explains its requirement for de-novo formation of centrosomes in mammalian cells.

Authors:  Ahuvit David; Hadar Amartely; Noa Rabinowicz; Mai Shamir; Assaf Friedler; Shai Izraeli
Journal:  Sci Rep       Date:  2016-04-14       Impact factor: 4.379
  6 in total

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