OBJECTIVES: The aim of this study was to evaluate the plasma levels of IL-17A in fibromyalgia patients, and to look for any correlations between this data and the concentrations of some pro- and anti-inflammatory cytokines. METHODS: We performed a study including 58 fibromyalgia patients and 39 healthy women matched for age and body mass index. The plasma levels of IL-17A and other pro- and anti-inflammatory cytokines were measured by using the technique of cytometric bead array (CBA). The analysis of differences between groups was performed using Mann-Whitney test and the analysis of the correlations by Spearman's correlation test. RESULTS: The analyses showed that fibromyalgia patients present increased levels of IL-17A. They also revealed that plasma concentrations of IL17A positively correlate with levels of IL-2, IL-4 and IL-10, TNF and IFNγ. CONCLUSIONS: As far as we are aware, this is the first study to demonstrate increased levels of IL17A in fibromyalgia patients. The positive correlation between the levels of IL-17A and of other cytokines strengthens the hypothesis of the involvement of inflammatory mechanisms in the development of this syndrome.
OBJECTIVES: The aim of this study was to evaluate the plasma levels of IL-17A in fibromyalgiapatients, and to look for any correlations between this data and the concentrations of some pro- and anti-inflammatory cytokines. METHODS: We performed a study including 58 fibromyalgiapatients and 39 healthy women matched for age and body mass index. The plasma levels of IL-17A and other pro- and anti-inflammatory cytokines were measured by using the technique of cytometric bead array (CBA). The analysis of differences between groups was performed using Mann-Whitney test and the analysis of the correlations by Spearman's correlation test. RESULTS: The analyses showed that fibromyalgiapatients present increased levels of IL-17A. They also revealed that plasma concentrations of IL17A positively correlate with levels of IL-2, IL-4 and IL-10, TNF and IFNγ. CONCLUSIONS: As far as we are aware, this is the first study to demonstrate increased levels of IL17A in fibromyalgiapatients. The positive correlation between the levels of IL-17A and of other cytokines strengthens the hypothesis of the involvement of inflammatory mechanisms in the development of this syndrome.
Authors: Theoharis C Theoharides; Irene Tsilioni; Lauren Arbetman; Smaro Panagiotidou; Julia M Stewart; Rae M Gleason; Irwin J Russell Journal: J Pharmacol Exp Ther Date: 2015-08-25 Impact factor: 4.030
Authors: Irene Tsilioni; Irwin J Russell; Julia M Stewart; Rae M Gleason; Theoharis C Theoharides Journal: J Pharmacol Exp Ther Date: 2016-01-13 Impact factor: 4.030
Authors: Iain B McInnes; Philip J Mease; Georg Schett; Bruce Kirkham; Vibeke Strand; Nicole Williams; Todd Fox; Luminita Pricop; Steffen M Jugl; Kunal K Gandhi Journal: Arthritis Res Ther Date: 2018-06-07 Impact factor: 5.156
Authors: M Ernberg; N Christidis; B Ghafouri; I Bileviciute-Ljungar; M Löfgren; J Bjersing; A Palstam; A Larsson; K Mannerkorpi; B Gerdle; E Kosek Journal: Mediators Inflamm Date: 2018-04-18 Impact factor: 4.711